Compilation of human mtDNA control region sequences

Handt, Oliva; Meyer, Sonja; Haeseler, Arndt von

doi:10.1093/nar/26.1.126

Cited by 85 publications

(56 citation statements)

References 33 publications

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“…22,23 In the HVRI network (Figure 3), the Hutterite sequences cluster fairly tightly together with the samples from South Tyrol, Austria, Germany, and Switzerland, and to a lower extent with the Russian samples. In the network for the mitochondrial coding region (Supplementary Figure S6), the Hutterite haplotypes are tightly connected to the samples from South Tyrol, but cluster also with samples from Czech Republic and Hungary, two populations that were not represented in the sample of the HVRI analysis.…”

Section: Studies Of Mtdnamentioning

confidence: 98%

“…The sample for the mtDNA analysis included 347 samples for the hypervariable region I (HVRI) from Austria (N¼87), Switzerland (N¼60), Germany (N¼100), and Russia (N¼100) 22 (http://www.hvrbase.de), and 51 samples for the mtDNA coding region from Czech Republic (N¼3), Hungary (N¼15), Volga-Ural region of Russia (N¼4), Ukraine (N¼1), and Russia (N¼28) 22,23 (http://www.hvrbase.de). In addition, also for the mtDNA analysis, a panEuropean reference dataset composed of 1124 individuals was used (http://www.hvrbase.de).…”

Section: Population Samplesmentioning

confidence: 99%

“…Median-joining networks for both the HVRI and the coding regions were constructed using the Hutterite and South Tyrolean data along with published HVRI sequences from Austria, Germany, Switzerland, and Russia, 22 and coding region sequences from Czech Republic, Hungary, Volga-Ural, Ukraine, and Russia. 22,23 In the HVRI network (Figure 3), the Hutterite sequences cluster fairly tightly together with the samples from South Tyrol, Austria, Germany, and Switzerland, and to a lower extent with the Russian samples.…”

Section: Studies Of Mtdnamentioning

confidence: 99%

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Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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Although the North American Hutterites trace their origins to South Tyrol, no attempts have been made to examine the genetic migration history of the Hutterites before emigrating to the United States in the 1870s. To investigate this, we studied 9 microsatellite loci and 11 unique event polymorphism (UEP) markers on the Y-chromosome, the hypervariable region I (HVRI) of the mitochondrial DNA (mtDNA), as well as the complete mtDNA genome of Hutterite and South Tyrolean samples. Only 6 out of 14 Y-chromosome UEP+microsatellite haplotypes and 3 out of 11 mitochondrial haplotypes that were present in the Hutterites were also present in the South Tyrolean population. The phylogenetic relationships inferred from Y-chromosome and mtDNA databases show that the Hutterites have a unique genetic background related to a similar extent to central and eastern European populations. An admixture analysis indicates, however, a relatively high genetic contribution of central European populations to the Hutterite gene pool. These results are consistent with historical records on Hutterite migrations and demographic history. In addition, our data reveal similar numbers of Y and mitochondrial haplotypes in Hutterite male and female founders, respectively. The Hutterite male and female gene pools are similar with respect to genetic diversity and genetic distance measures and comparable with respect to their origins, suggesting a similar evolutionary history.

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Section: Studies Of Mtdnamentioning

confidence: 98%

Section: Population Samplesmentioning

confidence: 99%

Section: Studies Of Mtdnamentioning

confidence: 99%

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Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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“…Relevant restriction sites for mtDNA haplogroup determination (Table 2) were selected from those 1 Pinto et al 1996 Galicia (Sp) 92 Salas et al 1998 HVRbase (Handt et al 1998) 1 Basque Country (Sp) 106 Bertranpetit et al 1995;HVRbase (Handt et al 1998) 1 Côrte-Real et al 1996 France (Fr) 50 Rousselet & Mangin, 1998 HVRbase (Handt et al 1998) 1 UK (UK) 100 Piercy et al 1993 HVRbase (Handt et al 1998) 1 Germany (Ger) 67 Hofmann et al 1997 HVRbase (Handt et al 1998) 1 Austria (Aus) 101 Parson et al 1998 HVRbase (Handt et al 1998) 1 Italy (It) 49 Francalacci et al 1996 HVRbase (Handt et al 1998) proposed by Torroni et al (1993Torroni et al ( , 1996, , Chen et al (1995), Macaulay et al (1999), Quintana-Murci et al (1999) and Saillard et al (2000). Some of the specific primers and PCR conditions for each polymorphic site were available from the literature, but others were designed in our laboratory (Montiel, 2001;Santos, 2001).…”

Section: Rflp Analysismentioning

confidence: 99%

“…The possible origin of the non-shared haplotypes, to be discussed later, was inferred using the partial networks presented in Figure 2 and two mtDNA databases, namely the database of and the HVRbase (Handt et al 1998), both available online.…”

Section: Phylogeography Of Azores Mtdnamentioning

confidence: 99%

Genetic Structure and Origin of Peopling in The Azores Islands (Portugal): The View from mtDNA

Santos

Lima

Montiel

et al. 2003

Annals of Human Genetics

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SummaryThe Azores islands (Portugal), uninhabited when discovered by Portuguese navigators in the fifteenth century, are located in the Atlantic Ocean 1500 km from the European mainland. The archipelago is formed by nine islands of volcanic origin that define three geographical groups: Eastern (S. Miguel and Sta. Maria), Central (Terceira, Faial, Pico, Graciosa and S. Jorge) and Western (Flores and Corvo). To improve the genetic characterisation of the Azorean population, and to clarify some aspects related to the history of settlement, a study of mtDNA was conducted in the population of the archipelago. The HVRI region was sequenced and specific RFLPs were screened in 146 samples obtained from unrelated individuals with Azorean ancestry (50 from the Eastern group, 60 from the Central group, and 37 from the Western group). Samples were classified into haplogroups based on the information obtained from both sequencing and RFLP analysis.All the analyses performed support the idea that, in the whole group of islands, the majority of mtDNA lineages originated from the Iberian Peninsula, mainly from Portugal (mainland). However contributions from other European populations, especially from Northern Europe, cannot be disregarded. The values obtained for the various diversity parameters in the Azores archipelago indicate that the Azorean population, as a whole, does not exhibit the typical characteristics of an isolated population. The analysis of genetic data by groups of islands showed that the Western group exhibited particular features. The distribution of haplogroups in the Western group is very atypical, being significantly different from what is observed in the Eastern and Central groups. Furthermore, the diversity values are, in general, lower than those observed in other populations used for comparison. African haplogroups were found in all the groups of islands. Therefore the presence of Moorish and African slaves on the islands, as reported in historical sources, is supported by the mtDNA genetic data, especially in the Eastern group. The presence of Jews in the Central group is also supported by the mtDNA data. Neither historical nor genetic data (phylogeography of mtDNA) supports the idea of a differential settlement history for the Western group; however, it is represented in the phylogenies as an isolated branch. The effect of genetic drift, induced by the reduced population size since peopling occurred, has led to a very atypical distribution of haplogroups/haplotypes in this group of islands.We cannot ignore the influence of biodemographic and genetic processes, namely founder effect, genetic drift, migration, and even recent mutational events in the mtDNA lineages of the Azorean populations. Nevertheless, a great part of the variation in the Azorean mtDNA can be explained by the settlement history.

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Mitochondrial DNA polymorphisms in Chilean aboriginal populations: Implications for the peopling of the southern cone of the continent

Moraga

Rocco

Miquel

et al. 2000

Am. J. Phys. Anthropol.

151

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The mitochondrial DNAs (mtDNAs) from individuals belonging to three Chilean tribes, the Mapuche, the Pehuenche, and the Yaghan, were studied both by RFLP analysis and D-loop (control region) sequencing. RFLP analysis showed that 3 individuals (1.3%) belonged to haplogroup A, 19 (8%) to haplogroup B, 102 (43%) to haplogroup C, and 113 (47.7%) to haplogroup D. Among the 73 individuals analyzed by D-loop sequencing, we observed 37 different haplotypes defined by 52 polymorphic sites. Joint analysis of data obtained by RFLP and sequencing methods demonstrated that, regardless of the method of analysis, the mtDNA haplotypes of these three contemporary South American aborigine groups clustered into four main haplogroups, in a way similar to those previously described for other Amerindians. These results further revealed the absence of haplogroup A in both the Mapuche and Yaghan as well as the absence of haplogroup B in the Yaghan. These results suggest that the people of Tierra del Fuego are related to tribes from south-central South America.

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Compilation of human mtDNA control region sequences

Cited by 85 publications

References 33 publications

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

Genetic Structure and Origin of Peopling in The Azores Islands (Portugal): The View from mtDNA

Mitochondrial DNA polymorphisms in Chilean aboriginal populations: Implications for the peopling of the southern cone of the continent

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