Competitive intra- and intermolecular interactions in secondary Mannich bases

Kołodziejczak, J.; Adamczyk‐Woźniak, Agnieszka; Sporzyński, Andrzej; Kochel, Andrzej; Koll, A.

doi:10.1016/j.molstruc.2010.03.076

Cited by 2 publications

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References 27 publications

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“…Extension of such studies on possible aggregation of the forms with intermolecular hydrogen bonds was possible due to the synthesis of the “secondary” Mannich bases with CH 2 –N(H)-alkyl moiety in works of Bujnowski et al , Secondary Mannich bases form simultaneously intramolecular and intermolecular hydrogen bonds. Competition of these two interactions was recently studied . Crystal structure determination, spectroscopic studies in solvents of different polarities, and theoretical calculations were performed.…”

Section: Introductionmentioning

confidence: 99%

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Intermolecular Interactions in the Solid State of Ionic Secondary Mannich Bases

Kołodziejczak

Adamczyk‐Woźniak

Hachuła

et al. 2012

Crystal Growth & Design

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Two new secondary Mannich bases, 4-bromo-2-[(aminopropyl)methyl]-phenol (1) and 4-nitro-2-[(aminopropyl)methyl]-phenol (2), were synthesized. Crystal structures were determined at liquid nitrogen temperature. It was found that in both compounds the proton transfer forms exist in the solid state. In the case of 1, this was unexpected, because of the weak acidity of p-bromophenol being the parent component of this Mannich base. The reason for that was found to be the formation of the O–···H–N+ hydrogen bonded tetramer in the solid state. Two cyclic aggregates R4 2(8) and R2 2(12) describe the pattern of hydrogen bonded interactions in the crystals of both compounds. Additionally, C–H···π interactions stabilize the crystal structures. The hydrogen bonds in 1 are slightly stronger (N···O distances 2.708 and 2.733 Å) than in 2 (2.721 and 2.765 Å, respectively) despite the fact that p-nitrophenol participating in 2 is a stronger acid. The influence of permittivity of surroundings and the hydrogen bonding pattern on the properties of intermolecular hydrogen bonds are discussed on the basis of B3LYP and MP2 calculations with basis sets 6-31+G(d,p) and 6-31++G(2d,2p). The coupling between hydrogen bonds in crystals was studied with the application of the IR spectra of isotopically diluted species. It was found that such a coupling is stronger for 2, forming weaker hydrogen bonds. Both the theory of IR spectra and quantum chemical calculations demonstrate that the source of the observed behavior is electronic participation in vibronic absorption.

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Section: Introductionmentioning

confidence: 99%

“…Competition of these two interactions was recently studied. 13 Crystal structure determination, spectroscopic studies in solvents of different polarities, and theoretical calculations were performed. The linear chains of intermolecular N−H•••O hydrogen bonds were found in the solid state, while intramolecular OH•••N hydrogen bonds also remained.…”

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confidence: 99%