Competitive interactions of chlorinated phenol compounds with 3,3′,5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water

Yamauchi, Kiyoshi; Ishihara, Akinori; Fukazawa, Hitoshi; Terao, Yoshiyasu

doi:10.1016/s0041-008x(02)00045-5

Cited by 86 publications

(42 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several environmental contaminants, due to their structural resemblance to THs (e.g., some metabolites and derivatives of PCBs and phenol compounds), may affect circulating TH levels by competing for their binding sites at transport proteins and interfering with TH homeostasis by binding TTR in vertebrates (Yamauchi et al, 2003;Boas et al, 2006;Morgado et al, 2007). Therefore, chemicals that interfere with TH binding to TTR may directly affect the free concentration of plasma THs and the plasma clearance rate of THs in fish.…”

Section: Discussionmentioning

confidence: 99%

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

et al. 2009

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

et al. 2009

View full text Add to dashboard Cite

“…Several environmental contaminants interfere with TH homeostasis by binding TTR in vertebrates (Yamauchi et al, 2003;Morgado et al, 2007a). The TTR is mainly expressed in the liver and brain (choroid plexus) in mammalians (Murakami et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery

Zha

Spear

et al. 2009

Aquatic Toxicology

View full text Add to dashboard Cite

a b s t r a c tThyroid hormones (THs) play an important role in the development and metabolism of fish through their influences on genetic transcription and are targets for endocrine disruptive agents in the aquatic environment. Amitrole is a pesticide potentially interfering with thyroid hormone regulation. In this study, the rare minnow (Gobiocypris rarus) was exposed to different levels of 3-amino-1,2,4-triazole (amitrole) and allowed to recover in clean water. Plasma TH levels and the expression of TH-related genes, including transthyretin (ttr), deiodinases (d1 and d2), and the thyroid hormone receptor (tr˛) from the livers and brains were evaluated. After exposure, the plasma TH levels did not change. Histopathological observations showed that livers were degenerated at 10,000 ng/l and these damages could be recovered by the withdrawal of amitrole. However, the ttr, d1, and d2 mRNA levels in the livers of males were significantly up-regulated in all exposure groups (p < 0.05). The ttr and d2 mRNA levels were significantly up-regulated at 10,000 ng/l and 10, 100, and 1000 ng/l in the livers of females, respectively (p < 0.05). In the brains of males, a twofold increase of d2 mRNA levels at ≥100 ng/l and a fivefold decrease of tr˛mRNA levels at ≥10 ng/l were observed (p < 0.05), whereas no significant differences were observed in the expression of d2 and tr˛in the brains of females. After a recovery period, the ttr, d1, and d2 mRNA levels in the livers of males returned to control levels, but the tr˛mRNA levels were irreversibly decreased at all treatments (p < 0.05). In addition, the d2 mRNA levels in the livers of females were significantly induced at ≥100 ng/l. Moreover, the d2 mRNA levels in the brains of males and females were up-regulated at 10,000 ng/l. These results indicated that amitrole exposure could result in alternations of ttr, d1, d2, and tr˛gene expression in different tissues of the rare minnow. The expression of these TH-related genes in males was more sensitive to amitrole than those of females. Recovery in clean water was associated with the selective regulation of TH-related gene transcription in the rare minnow. Therefore, these TH-related genes can serve as biomarkers to screen the effects of thyroid disruption chemicals in rare minnow.

show abstract

“…Detection of chlorinated or nitro compounds in the environments is a very important problem because they affect human lives as the relics of agricultural chemicals or explosives [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca2+

Motoyoshiya

Fengqiang

Nishii

et al. 2008

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

View full text Add to dashboard Cite

The fluorescence quenching behavior of two distyrylbenzenes (DSBs) newly prepared bearing strongly electron-donating groups was investigated. Several chlorinated and nitro compounds quench the fluorescence of both DSBs with various efficiencies depending on the electron-withdrawing properties; the strongly electron-withdrawing compound, such as 2,4,5-trichlorophenol and 2,4-dinitrofluorobenzene, effectively diminish the fluorescence intensities of the DSBs. Since the fluorescence quenching constants and the reduction potentials of the quenchers are linearly related, these quenching phenomena are attributed to the photo-induced electron transfer (PET) process. The fluorescence quenching was also detected in the interaction between the azacrown DSB and phenylboronic acid, while the fluorescence recovers by adding triethylamine. On the other hand, the azacrown DSB selectively interacts with Ca 2+ to decrease its fluorescence intensity, but the DSB with the dimethylamino groups did not. These results suggest a potential use of these types of compounds as sensors for strongly electron-withdrawing substances and a suitable metal cation.

show abstract

Competitive interactions of chlorinated phenol compounds with 3,3′,5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water

Cited by 86 publications

References 36 publications

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery

Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca2+

Contact Info

Product

Resources

About