Competitive Host‐guest Electrochemical Detection of Ivermectin Drug Using a β‐Cyclodextrin/Graphene‐based Electrode

Abstract

The present study describes the novel development and application of an ivermectin (IVM) sensing electrochemical platform based on reduced graphene oxide (rGO) and the macrocyclic host β-cyclodextrin (β-CD) molecule. The sensing method was based in the hostguest characteristics of β-CD and competitive interaction between the target analyte and the methylene blue (MB) redox probe. Differential pulse voltammetry (DPV) was employed for the detection of IVM and a linear response between 0.5 and 40.0 μmol L À 1 with a limit of detection of 0.25 μmol L À 1 was obtained using the glassy carbon (GC)/ rGO/β-CD electrode. The sensing platform was successfully applied for the detection of IVM in tap water samples, which may expand the applications of β-CD towards the analysis of other chemical species.

Lab-made CO2 laser-engraved electrochemical sensors for ivermectin determination

“…The literature mainly reports the use of modied electrodes for IVM determination in several samples, especially glassy carbon disc electrodes, which were modied with reduced graphene doped with silver nanoparticles decorated B and S heteroatoms, 9 glutaraldehyde 10 and b-cyclodextrin/graphene. 11 Alternatively, a boron-doped diamond electrode coupled with Flow Injection Analysis (FIA) system was also reported for IVM determination. 12 Graphene and its derivatives have been employed as a chemical modier of electrodes in the development of electroanalytical methods, owing to its large their remarkable properties, including a good electrical conductivity and exibility of operation.…”

“…The literature mainly reports the use of modified electrodes for IVM determination in several samples, especially glassy carbon disc electrodes, which were modified with reduced graphene doped with silver nanoparticles decorated B and S heteroatoms, 9 glutaraldehyde 10 and β-cyclodextrin/graphene. 11 Alternatively, a boron-doped diamond electrode coupled with Flow Injection Analysis (FIA) system was also reported for IVM determination. 12…”

An electrochemical chiral sensor based on competitive host–guest interaction for the discrimination of electroinactive amino acids

“…More importantly, MB can enter the inner cavity of β-CD via a host–guest interaction. 17,18 Therefore, the inclusion complex of β-CD and MB can be utilized for the detection of electroinactive substances. 19 For example, Hao et al .…”

“…More importantly, MB can enter the inner cavity of β-CD via a host-guest interaction. 17,18 Therefore, the inclusion complex of β-CD and MB can be utilized for the detection of electroinactive substances. 19 For example, Hao et al 20 proposed an electrochemical sensing strategy for amantadine detection based on the competitive host-guest interaction of MB/β-CD and amantadine/β-CD.…”