Competition of n-3 and n-6 Polyunsaturated Fatty Acids in the Isolated Perfused Rat Heart

Fragiskos, Bill; Chan, Alvin C.; Choy, Patrick C.

doi:10.1159/000177211

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…Feeding cod liver oil was shown to enrich rat heart tissue with n-3 fatty acids (Gudbjarnason and Oskarsdottir, 1977). Rat hearts perfused with eicosapentaenoic acid also demonstrated incorporation of this fatty acid into the cardiac muscle phospholipids (Fragiskos et al, 1986). In the present experiment, liver and heart tissues from chickens fed the higher levels of MO had lower concentrations of 20:4n6. The reduced levels of 20:4n6 might be due to n -3 polyunsaturates inhibiting the synthesis of 20:4n6 from linoleic acid (18:2n6), as suggested by Edward and Marion (1963) and , or the lower levels of dietary 18:2n6.…”

Section: Discussionsupporting

confidence: 50%

Lipid measurements in chickens fed different combinations of chicken fat and menhaden oil

Phetteplace¹,

Watkins²

1990

J. Agric. Food Chem.

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Section: Discussionsupporting

confidence: 50%

Lipid measurements in chickens fed different combinations of chicken fat and menhaden oil

Phetteplace¹,

Watkins²

1990

J. Agric. Food Chem.

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“…with little or no change in the total lipid content. These finding are consistent with the reports of others who have indicated a displacement of arachidonic acid by n-3 fatty acids, in both in vivo and in vitro studies [16,17,22], Although many studies have described the potentially beneficial effects of increasing the amount of n-3 fatty acids in the diet, this has not been supported by all reports [8,23]. It may be that these differences relate to the degree and duration of supplementation.…”

Section: Discussionsupporting

confidence: 89%

A High Omega 3 Fatty Acid Diet Alters Fatty Acid Composition of Heart, Liver, Kidney, Adipose Tissue and Skeletal Muscle in Swine

Otten¹,

Wirth²,

Iaizzo³

et al. 1993

Ann Nutr Metab

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The fatty acid profiles and total lipid contents of two skeletal muscles, adipose tissue, heart, liver and kidney of swine fed a diet rich in omega 3 (n-3) fatty acids (i.e., 5% fish oil) was investigated. These values were compared to those determined for animals which were fed an equal caloric diet low in n-3 fatty acids (i.e., 5% coconut oil). All supplementations were given over a 13-week period. The lipids were extracted with chloroform-methanol, transesterified and the relative fatty acid methylesters concentrations were determined using capillary gas chromatography. The fish oil diet significantly enhanced the relative amounts of n-3 fatty acids (i.e., eicosapentaenoic acid and docosahexaenoic acid) in all tissues examined. In the heart, liver and kidney, the increases in n-3 fatty acids were compensated by decreases primarily in arachidonic acid, but in the other tissues the contents of lauric and myristic acids were also reduced. In general, the n-3 fatty acid contents were 40-165% higher in the animals fed the fish oil. Supplementation of n-3 fatty acids in swine induced a significant incorporation of these fatty acids throughout the body, however the extent of this incorporation differed between tissues perhaps due to tissue-specific metabolic pathways.

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“…Although a lot has been written about the effect of dietary n-3 fatty acids on the fatty acid composition of human and other mammalian body fluids and organs (130)(131)(132)(133)(134)(135)(136), as well as on eicosanoid metabolism (20,27,39,115,131,137,138), this review only refers to the data related to absorption and transport of n-3 fatty acids.…”

Section: Absorption Of N-3 Fatty Acidmentioning

confidence: 99%

Absorption and transport of fat in mammals with emphasis on n−3 polyunsaturated fatty acids

Nelson

Ackman

1988

Lipids

117

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The current state of knowledge concerning the absorption and transport of dietary fat with emphasis on long-chain polyunsaturated n-3 fatty acids in mammals is reviewed. It is apparent that long-chain polyunsaturated n-3 fatty acids, either as free acids or as part of triglycerides, are readily absorbed in the gut and transported by the circulatory system. Indeed, it would appear that long-chain polyunsaturated n-3 fatty acids are digested, absorbed and transported similarly to other long-chain fatty acids with only minor variations, although there is much that is still not understood about these processes. The main unresolved issues in the area of the absorption and transport of long-chain polyunsaturated n-3 fatty acids appear to be: 1) If they, when located in the 2-position of triglycerides, have unique metabolic pathways; and 2) whether the unnatural forms, i.e., methyl or ethyl ester derivatives, are suitable vehicles for administration as dietary supplements. The effect in man of dietary, long-chain polyunsaturated n-3 fatty acids on blood serum lipid and lipoprotein levels, particularly the low density lipoproteins, remains controversial, except for the well-documented reduction in serum triglyceride levels. Also, there is uncertainty regarding their distribution and metabolism in tissues. Finally, if the consumption of long-chain polyunsaturated n-3 fatty acids has beneficial health consequences, what is the appropriate therapeutic dose? In view of these important, unresolved issues and uncertainties, it would seem prudent to direct additional research toward a better understanding of the overall process by which fat is digested, absorbed and transported.

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Competition of n-3 and n-6 Polyunsaturated Fatty Acids in the Isolated Perfused Rat Heart

Cited by 11 publications

References 7 publications

Lipid measurements in chickens fed different combinations of chicken fat and menhaden oil

Lipid measurements in chickens fed different combinations of chicken fat and menhaden oil

A High Omega 3 Fatty Acid Diet Alters Fatty Acid Composition of Heart, Liver, Kidney, Adipose Tissue and Skeletal Muscle in Swine

Absorption and transport of fat in mammals with emphasis on n−3 polyunsaturated fatty acids

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