Competition between physical search and a weak-to-strong transition rate-limits kinesin binding times
Trini Nguyen,
Babu Reddy Janakaloti Narayanareddy,
Steven P. Gross
et al.
Abstract:The self-organization of cells relies on the profound complexity of protein-protein interactions. Challenges in directly observing these events have hindered progress toward understanding their diverse behaviors. One notable example is the interaction between molecular motors and cytoskeletal systems that combine to perform a variety of cellular functions. In this work, we leverage theory and experiments to identify and quantify the rate-limiting mechanism of the initial association between a cargo-bound kines… Show more
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