Competing risk of the specific mortality among Asian-American patients with prostate cancer: a surveillance, epidemiology, and end results analysis

Abstract

Background Adopted the competing-risk model to investigate the relevant factors affecting the prostate cancer (PCa)-specific mortality among Asian-American PCa patients based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods The information of 26,293 Asian-American patients diagnosed with PCa between 2004 and 2015 were extracted from the SEER 18 database. Subjects were divided into three groups: died of PCa, died of other causes, survival based on the outcomes at the end of 155 months’ follow-up. Multivariate analysis was performed by the Fine-gray proportional model. Meanwhile, subgroup analyses were conducted risk stratification by race and age. Results Age ≥ 65 years [Hazard ratio (HR) = 1.509, 95% confidence interval (CI) 1.299–1.754], race (HR = 1.220, 95% CI 1.028–1.448), marital status (unmarried, single or widowed, HR = 1.264, 95% CI 1.098–1.454), tumor grade II (HR = 3.520, 95% CI 2.915–4.250), the American Joint Committee on Cancer (AJCC) stage (T3: HR = 1.597, 95% CI 1.286–1.984; T4: HR = 2.446, 95% CI 1.796–3.331; N1: HR = 1.504, 95% CI 1.176–1.924; M1: HR = 9.875, 95% CI 8.204–11.887) at diagnosis, radiotherapy (HR = 1.892, 95% CI 1.365–2.623), regional nodes positive (HR = 2.498, 95% CI 1.906–3.274) increased risk of PCa-specific mortality for Asian-American PCa patients, while surgical (HR = 0.716, 95% CI 0.586–0.874) reduced the risk. Conclusion The study findings showed that age, race, marital status, tumor grade (II), AJCC stages (T3, T4, N1, M1) at diagnosis, radiotherapy, regional nodes positive and surgery was associated with the specific mortality of PCa patients among Asian-Americans.

Completeness of variables in Hospital-Based Cancer Registries for prostatic malignant neoplasm

“…“Race/skin color” is an important variable in the study of prostate cancer, as some ethnicities are risk factors for the development of this cancer, such as Africans and Asians, presenting higher incidence rates and shorter survival times for this neoplasm ( 5 , 25 ) . In other words, this variable merely transcends a biological distinction.…”

“…“Raça/cor da pele” é uma variável importante no estudo do câncer de próstata, pois algumas etnias são fatores de risco para desenvolvimento desse câncer, como africana e asiática, apresentando maiores taxas de incidência e menor tempo de sobrevida para essa neoplasia ( 5 , 25 ) . Ou seja, essa variável transcende meramente uma distinção biológica.…”

Incompleteness trends of epidemiological variables in a Brazilian high complexity cancer registry: An ecological time series study

“…In the context of prostate cancer studies, the race/skin color variable holds immense significance due to the higher incidence and lower survival rates observed in individuals of African and Asian origin. [5,24] It should be noted that this variable encompasses more than just biological differences; it represents a complex variable that encapsulates socioeconomic and cultural factors, highlighting inequities in accessing healthcare, particularly in cancer diagnosis and treatment. Our findings align with other research conducted in Brazil.…”