Compensatory Renal Hypertrophy: A Morphologic Study in Transplant Donors

Orecklin, James R.; Craven, J. Duncan; Lecky, James W.

doi:10.1016/s0022-5347(17)60591-3

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…The maximal fractional change in length in this series was 9-5 per cent and the average increase in length was 3-3 per cent. This average is less than that found by Boner et al (1972) and Orecklin et al (1973) in transplant donors. However, this may be because the removed kidney in the series reported here was not always entirely normal.…”

Section: R S Dossetorcontrasting

confidence: 59%

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Renal compensatory hypertrophy in the adult

Rs¹

1975

BJR

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Compensatory renal enlargement was assessed in 19 adult patients who either had a nephrectomy (17 cases) or developed a functionless kidney following obstruction (two cases). Hypertrophy of the healthy kidney was assessed by comparing renal size on urography before and after removal or destruction of the diseased kidney. Compensatory renal enlargement was demonstrated in 40 per cent of the patients, including two patients in their sixties. The average increase in length was 3 per cent and the maximum increase in length was 9 per cent. Therefore compensatory enlargement does occur in adult life, but is much less than that occurring in childhood. The presence of a hypertrophied adult kidney over 17 cm in length usually indicates that the contralateral renal disease was present in childhood.

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Section: R S Dossetorcontrasting

confidence: 59%

“…48,No. 576 Boner, Sherry and Rieselbach (1972) and Orecklin, Craven and Lecky (1973) found fractional changes in length of the remaining kidney in adult transplant donors of 10-56 per cent and 8-4 per cent respectively. (The latter figure is deduced from their change in renal area of 16-8 per cent.…”

Section: Compensatory Renal Enlargement In Adultsmentioning

confidence: 98%

Renal compensatory hypertrophy in the adult

Rs¹

1975

BJR

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“…The size of the hypertrophied kidney at the last determination was 135 to 165 % of normal. In previous studies of kidney donors, the size of the remaining kidney has generally not been more than 25% larger than normal (5,20). In most of those studied, however, the time from operation to the recording of kidney size has been shorter than 48 months.…”

Section: Actri P;pdiritr S W N D 66mentioning

confidence: 82%

Renal Growth and Function in Patients Nephrectomized in Childhood

et al. 1977

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Eight patients nephrectomized in childhood were studied with regard to growth and function of the remaining kidney. The age of the patients ranged between 8 1/2 and 31 years and the follow-up period was from 1 to 20 years. In most of the patients, repeated renal size determinations were made on postoperative urograms. Normal values for kidney size in childhood are also presented. The structural hypertrophy continued for at least three years after nephrectomy and was most pronounced in patients nephrectomized before three years of age. When more than three years had passed after nephrectomy the remaining kidney was 35-65% larger than normal. Healthy young adults and children with a previous history of urinary tract infection served as controls for function studies. The balance between glomerular and tubular function was well preserved in nephrectomized patients. The renal surface area showed the same relation to GFR and to reabsorption of bicarbonate in nephrectomized patients as in controls. It is therefore concluded that the increase in kidney function following unilateral nephrectomy is, at least in early life, primarily due to structural enlargement.

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“…The size of the remaining kidney in the Hn group was 142% of normal. i n studies of kidney donors nephrectomized in adulthood, the remnant kidney is rarely enlarged by more than 25% (18,19). Several studies have been published concerning the function and radiological appearance of the remnant kidney in the W patients who were treated with radiation and chemotherapy (20-25).…”

Section: Dicussionmentioning

confidence: 99%

A Comparative Study of Size and Function of the Remnant Kidney in Patients Nephrectomized in Childhood for Wilms’Tumor and Hydronephrosis

et al. 1986

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To obtain more information about the natural history of compensatory renal hypertrophy beginning in childhood we traced those who were nephrectomized in childhood for Wilm's tumor (W) and hydronephrosis (Hn) between 1950 and 1978 at one department of surgery in Stockholm. All W patients had received treatment that suppresses cellular division. None of the patients were in renal failure or treated with antihypertensive drugs. All the patients in the follow-up study (22 W, 15 Hn) had a normal contralateral kidney at nephrectomy. Five healthy adults served as controls. The kidney was enlarged in both Hn (142%) and W (125%), but significantly larger in Hn than in W. Renal compensatory growth in W was retarded during the first two years after nephrectomy. The glomerular filtration rate (GFR) was 92% of control in Hn and 82% of control in W. The GFR did not seem to decline with a longer follow-up time in any of the groups. PAH clearance was the same in Hn and W. Albumin excretion was significantly higher in Hn than in W, but not significantly higher in W than in controls. The highest albumin excretion rates were found among the Hn patients with long follow-up time. The results suggest that the large increases in size and function that follow childhood nephrectomy can be blunted by antimitotic agents.

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Compensatory Renal Hypertrophy: A Morphologic Study in Transplant Donors

Cited by 11 publications

References 13 publications

Renal compensatory hypertrophy in the adult

Renal compensatory hypertrophy in the adult

Renal Growth and Function in Patients Nephrectomized in Childhood

A Comparative Study of Size and Function of the Remnant Kidney in Patients Nephrectomized in Childhood for Wilms’Tumor and Hydronephrosis

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