Compensatory reaction during degeneration of arcuate nucleus dopaminergic neurons in rats

Ziyazetdinova, Guzel; Sapronova, A. Ya.; Kiyasov, V. Ya.; Nanaev, A. K.; Кудрин, В. С.; N, Martina; Tillier, I.; Ugrumov, M. V.

doi:10.1134/s0022093008010106

Cited by 4 publications

(3 citation statements)

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“…in neurodegenerative diseases like hyperprolactinemia and Parkinson's disease . Indeed, the neurotoxin-induced degeneration of DA-ergic neurons in the AN is followed first by the degeneration of 50% DAergic neurons and the 50% decrease of DA synthesis and then by the increase of the number of monoenzymatic TH and AADC neurons and the restoration of DA synthesis (Ershov et al, 2005;Ziyazetdinova et al, 2008). Similar reaction is a characteristic of the striatal monoenzymatic neurons as their number increases significantly after the degeneration of the nigral DA-ergic neurons (Betarbet et al, 1997;Cossette et al, 2005a).…”

Section: Ensembles Of Monoenzymatic Th Neurons and Aadc Neuronsmentioning

confidence: 89%

Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Ugrumov

2009

Journal of Chemical Neuroanatomy

114

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Section: Ensembles Of Monoenzymatic Th Neurons and Aadc Neuronsmentioning

confidence: 89%

Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Ugrumov

2009

Journal of Chemical Neuroanatomy

114

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“…AADC : décarboxylase des amino-acides aromatiques ; TH : tyrosinehydroxylase ; ovale gris : transporteur membranaire commun aux amino-acides neutres et à la DOPA. -d) montrant que la dégénérescence induite par la 6-hydroxy-dopamine de 50 % des neurones bienzymatiques (TH&AADC) dans le noyau arqué de rats adultes est suivie tout d'abord par une diminution de la synthèse de dopamine (DA) et une sécrétion accrue de prolactine après 14 jours, puis par une normalisation des deux paramètres après 45 jours (Ugrumov 2008 ;Ziyasetdinova et al, 2008). De plus, le nombre de neurones monoenzymatiques augmente significativement à 45 jours (Ershov et al, 2005).…”

Section: Parkinson's Diseaseunclassified

“…En vue de tester notre hypothèse d'un rôle compensatoire de la synthèse coopérative de dopamine, une déficience dans le système tubéro-infundibulaire dopaminergique a été provoquée chez le rat par une injection intraventriculaire de 6-hydroxy-dopamine qui provoque la dégénérescence de 50 % des neurones dopaminergiques bienzymatiques, une diminution significative de la synthèse de dopamine et une augmentation de 100 % de la concentration de prolactine dans le plasma au quatorzième jour (Fig. 7) (Ziyasetdinova et al, 2008). Il est intéressant de noter que la synthèse de dopamine et la prolactinémie retournent à un niveau normal quarante-cinq jours après l'injection de neurotoxine (Fig.…”

Section: Parkinson's Diseaseunclassified

Synthèse de monoamines par des neurones non-monoaminergiques. Illusion ou réalité ?

Ugrumov¹

2009

J. Soc. Biol.

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In contrast to monoaminergic (MA-ergic) neurons possessing the whole set of the enzymes for MA synthesis from the precursor amino-acid, some, mostly peptidergic, neurons co-express only one of the enzymes of monoamine synthesis. They are widely distributed in the brain, being particularly numerous in ontogenesis and, in adulthood, under certain physiological conditions. Most monoenzymatic neurons possess one of the enzymes for dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). TH and AADC are enzymatically active in a substantial number of monoenzymatic neurons, where they are capable of converting L-tyrosine to L-3,4-dihydroxy-phenylalanine (L-DOPA) and L-DOPA to dopamine (DA) (or 5-hydroxy-tryptophan, 5-HTP to serotonin), respectively. According to our data L-DOPA synthesized in monoenzymatic TH-neurons is released and taken up by monoenzymatic AADC-neurons for DA synthesis. Moreover, L-DOPA captured by dopaminergic neurons and serotoninergic neurons serves to stimulate dopamine synthesis in the former and to start DA synthesis in the latter. Cooperative synthesis of MAs is considered as a compensatory reaction under a failure of MA-ergic neurons, e.g. in neurodegenerative diseases like hyperprolactinemia and Parkinson's disease, which are developed primarily because of degeneration of DA-ergic neurons of the tuberoinfundibular system and the nigrostriatal system, respectively. Noteworthy, the neurotoxin-induced increase of prolactin secretion returns with time to a normal level due to the stimulation of DA synthesis by the tuberoinfundibular most probably monoenzymatic neurons. The same compensatory mechanism is supposed to be used under the failure of the nigrostriatal DA-ergic system that is manifested by an increased number of monoenzymatic neurons in the striatum of animals with neurotoxin-induced parkinsonism and in humans with Parkinson's disease. Expression of the enzymes of MA synthesis in non-monoaminergic neurons is controlled by intercellular signals such as classical neurotransmitters (catecholamines), etc. Thus, a substantial number of brain neurons express partly the monoaminergic phenotype, namely individual complementary enzymes of MA synthesis, serving to produce MAs in cooperation, which is considered as a compensatory reaction under the failure of MA-ergic neurons.

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Brain Neurons Partly Expressing Dopaminergic Phenotype

Ugrumov

2013

Advances in Pharmacology

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Compensatory reaction during degeneration of arcuate nucleus dopaminergic neurons in rats

Cited by 4 publications

References 16 publications

Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Non-dopaminergic neurons partly expressing dopaminergic phenotype: Distribution in the brain, development and functional significance

Synthèse de monoamines par des neurones non-monoaminergiques. Illusion ou réalité ?

Brain Neurons Partly Expressing Dopaminergic Phenotype

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