Compensatory pressor role of vasopressin following acute diuresis

Interactions Between Furosemide and the Renal Sympathetic Nerves

“…Thus, increased plasma levels of vasoconstrictor substances and/or decreased plasma levels of hormones with vasodilator actions could mediate arteriolar vasoconstriction. This hypothesis is supported by numerous studies which have demonstrated increased plasma levels of norepinephrine, epinephrine, vasopressin, and angiotensin I1 during acute furosemide administration in both rat (DiPette & Rogers 1988;Petersen et al 1992), dog (Ueno et al 1980;Ueno et al 1983) and humans (Hesse et al 1975;Van Hooff et al 1983;Canella et al 1983;Kelly et al 1983;Francis et al 1985;Kubo et al 1987;Goldsmith et al 1989;Passmore et al 1989;Fujimura & Ebihara 1990;Okaniwa et al 1990;Jespersen et al 1991). The plasma concentration of the vasodilator hormone atrial natriuretic peptide decreases during furosemide diuresis, whereas furosemide produces an increase in both circulating and urinary excretion of prostaglandin E2 Dupont et al 1988;Fujimura & Ebihara 1990;Okaniwa et al 1990;Jespersen et al 1991).…”