Compensatory eythropoiesis during routine autologous blood donation

The variability of compensatory erythropoiesis in repeated autologous blood donation

“…Several studies on the efficacy of PABD have consistently shown that compensatory erythropoiesis is subject to hitherto unexplained interindividual variability 1–6 . It was the goal of the present study to identify variables that might allow us to predict the extent of production of RBCs during repeated PABD in an individual patient.…”

“…It is a common finding that compensatory RBC production during repeated preoperative autologous blood donation (PABD) shows marked interindividual variability 1–6 …”

Declining value of preoperative autologous donation

“…Several studies have demonstrated that preoperative Hb is decreased in patients who have participated in PABD programs. In the absence of erythropoietin therapy, compensatory erythropoiesis does not fully compensate for the amount of Hb lost in preoperative donations, and PABD performed 1 or 2 weeks before surgery is essentially a form of hemodilution 4,9 . These patients, therefore, would almost certainly not have required any allogeneic transfusions if they had not participated in a PABD program.…”

A Randomized Trial of Acute Normovolemic Hemodilution Compared to Preoperative Autologous Blood Donation in Total Knee Arthroplasty

“…Recently it has been proposed that PAD be redefined as ‘chronic hemodilution’, in reference to the poor compensatory erythropoietic response associated with PAD under routine conditions of 1 unit collected weekly [32]. Since most blood loss in knee arthroplasty occurs after the release of the tourniquet [33], the value of postoperative blood salvage and reinfusion has been scrutinized [34].…”