Compensatory Changes in the Function of the Remaining Kidney Immediately after Unilateral Nephrectomy in Sheep

Ziada, G.; Youseif, Husein; Khalil, Magdy M.

doi:10.1620/tjem.219.165

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Our results showed a borderline correlation between the V/W ratio and eGFR at 1 year after kidney removal as well. It is known that upon kidney removal, the effective renal blood flow of the remnant kidney increases immediately [20,21]; consequently, it will work at a compensatory state and the GFR will increase. Our previous study have shown that the volume of remnant kidney was negatively associated with volume increment after nephrectomy and the kidney with larger volume compensation had lower serum creatinine, indicating that small kidneys may have better function compensation [22].…”

Section: Discussionmentioning

confidence: 99%

Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors

Song

Rao

Qiu

et al. 2016

The Kaohsiung J of Med Scie

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To investigate whether the ratio of remnant kidney volume to body weight (V/W ratio) can impact renal function in donors, 45 living kidney donors were enrolled. Kidney volume was analyzed by magnetic resonance imaging. Renal function was compared between donors with a V/W ratio of < 2.0 mL/kg (n = 23) or ≥ 2.0 mL/kg (n = 22). Donors in both V/W groups showed similar serum creatinine levels and estimated glomerular filtration rates (eGFRs) at 7 days and 1 year, whereas donors with a V/W ratio of < 2.0 mL/kg had significantly higher 24-hour urine protein levels at 1 year (0.54 ± 0.23 g/d vs. 0.33 ± 0.19 g/d, p = 0.028). Multivariate analysis revealed no correlation between the V/W ratio and eGFR at 7 days or 1 year, and a V/W ratio of < 2 mL/kg was not associated with an increased incidence of eGFR < 60 mL/min/1.73 m(2) at 1 year (risk ratio 1.73, 95% confidence interval 0.10-29.47). The V/W ratio correlated inversely with 24-hour urine protein (r = -0.377, p = 0.021) at 1 year, and donors with a V/W ratio of < 2.0 mL/kg were more likely to show 24-hour urine protein >300 mg (risk ratio 1.70, 95% confidence interval 1.08-2.67) at 1 year. Donors with lower V/W ratios have higher 24-hour urinary protein levels at 1 year after transplantation. These findings suggest that the V/W ratio may be useful for kidney selection.

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Section: Discussionmentioning

confidence: 99%

Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors

Song

Rao

Qiu

et al. 2016

The Kaohsiung J of Med Scie

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“…However, after UN, the glomerular filtration rate increased by only 52.3%. 24 UN is therefore an efficient method for inducing pancreatic damage and hastening the onset of STZ-induced DM.…”

Section: Discussionmentioning

confidence: 99%

A novel mouse model of diabetes mellitus using unilateral nephrectomy

et al. 2015

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Diabetes mellitus (DM) is a major cause of morbidity and mortality worldwide, and its complications are prominent public health issues. Many experimental models of streptozotocin (STZ)-induced and high-fat diet (HF)-induced DM have been used to study this disease. Studies have indicated that unilateral nephrectomy (UN) accelerates the development of diabetic nephropathy. We hypothesized that UN stimulates HF and STZ combination-induced DM in mice. Seventy-two female C57BL/6J mice were divided into four treatment groups: HF; HF + STZ120 (HF and STZ, 120 mg/kg); UN + HF + STZ120 (UN, HF and STZ, 120 mg/kg); and HF + STZ200 (HF and STZ, 200 mg/kg). Onset of DM, survival rate, blood pressure, urine glucose level, and pancreatic histology were investigated. Additionally, renal function was evaluated in the UN + HF + STZ120 group after STZ injection. DM was induced in the UN + HF + STZ120 and HF + STZ200 groups within one week. The UN + HF + STZ120 group had lower mortality than the HF + STZ200 group and greater pancreatic destruction than the HF and HF + STZ120 groups. Two weeks after STZ injection, blood pressure was not significantly different among the groups. Nephrotoxicity associated with the combination of UN and STZ was not observed. In conclusion, the combination of these three techniques--UN, HF and STZ induced DM rapidly and effectively.

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“…An animal model has shown that the GFR of the remnant kidney increases by 52.3 % immediately after nephrectomy [17]. Several studies have examined the effects of renal donation on the remaining kidney.…”

Section: Discussionmentioning

confidence: 99%

Change in renal function following laparoscopic donor nephrectomy using 99 mTc-diethylenetriaminepentaacetic acid scan

et al. 2014

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Compensatory Changes in the Function of the Remaining Kidney Immediately after Unilateral Nephrectomy in Sheep

Cited by 9 publications

References 29 publications

Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors

Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors

A novel mouse model of diabetes mellitus using unilateral nephrectomy

Change in renal function following laparoscopic donor nephrectomy using 99 mTc-diethylenetriaminepentaacetic acid scan

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