Compensation programs after withdrawal of the recommendation for HPV vaccine in Japan

Kikuchi, Yuji; Nakada, Haruka

doi:10.1080/21645515.2015.1107686

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…There is very low job mobility in Japan ( 24 ). Working for a single company was considered ideal in the period of high economic growth after the Second World War.…”

Section: Discussionmentioning

confidence: 99%

Encouraging Cross-Disciplinary Collaboration and Innovation in Epidemiology in Japan

Yokomichi

Mochizuki

Yamagata

2021

Front. Public Health

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Background: Scientific innovation is often achieved through the intersection of ideas from different fields. However, barriers prevent non-epidemiologists from cultivating interests in epidemiology or undertaking epidemiologic work. In this study, we evaluated changes in the diversity of research topics in an epidemiologic journal over time. We aimed to understand how epidemiologists and non-epidemiologists communicate about epidemiologic data and how this impacts innovation in the field.Methods: We categorized the topics of articles published in the Journal of Epidemiology during the early and late 2010s based on their titles. We calculated the Shannon–Weaver diversity index (H′) to measure changes in the diversity of topics addressed by published articles.Results: Comparing 2011–2013 with 2017–2019, there was no significant change in the diversity of article topics (H′ = 4.25 and 4.21, respectively) published in the Journal of Epidemiology.Conclusion: To encourage healthcare providers and public administrators to conduct or comment on epidemiologic studies, epidemiologists should present their findings in easily understood language with appropriate and relevant statistical indicators and useful illustrations. Bringing experience from other specialties into epidemiology may yield new findings from epidemiologic data because of the exposure of non-epidemiologists to different values, workplaces, and occupations. Collaboration among professionals from varied backgrounds and with varied occupational experiences may help to promote scientific innovation by broadening perspectives. In addition, a range of professional experiences may enable individuals to solve difficult research questions more easily by themselves.

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“…There is very low job mobility in Japan ( 24 ). Working for a single company was considered ideal in the period of high economic growth after the Second World War.…”

Section: Discussionmentioning

confidence: 99%

Encouraging Cross-Disciplinary Collaboration and Innovation in Epidemiology in Japan

Yokomichi

Mochizuki

Yamagata

2021

Front. Public Health

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“…Cervical cancer is a serious health concern, and is due to persistent infection with high-risk subtypes of HPV, including types 16, 18, 31, and 45 (Yuji and Nakada, 2016 ). Preventive vaccines for cervical cancer do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions, and thus recent advances in immunotherapy treatment of cervical cancer have gained much attention lately (Yang M. C. et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

A Genetically Modified attenuated Listeria Vaccine Expressing HPV16 E7 Kill Tumor Cells in Direct and Antigen-Specific Manner

Jia

Tan

Duan

et al. 2017

Front. Cell. Infect. Microbiol.

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Attenuated Listeria monocytogenes (L. monocytogenes, LM) induces specific CD8+ and CD4+ T cell responses, and has been identified as a promising cancer vaccine vector. Cervical cancer is the third most common cancer in women worldwide, with human papillomavirus (HPV), particularly type 16, being the main etiological factor. The therapeutic HPV vaccines are urgently needed. The E7 protein of HPV is necessary for maintaining malignancy in tumor cells. Here, a genetically modified attenuated LM expressing HPV16 E7 protein was constructed. Intraperitoneal vaccination of LM4Δhly::E7 significantly reduced tumor size and even resulted in complete regression of established tumors in a murine model of cervical cancer. We provided evidence that recombinant LM strains could enter the tumor tissue and induce non-specific tumor cell death, probably via activation of reactive oxygen species and increased intracellular Ca2+ levels. LM4Δhly::E7 effectively triggered a strong antigen-specific cellular immunity in tumor-bearing mice, and elicited significant infiltration of T cells in the intratumoral milieu. In summary, these data showed LM4Δhly::E7 to be effective in a cervical cancer model and LM4Δhly::E7 induced an antitumor effect by antigen-specific cellular immune responses and direct killing of tumor cells, indicating a potential application against cervical cancer.

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“…However, there is a small risk of adverse reactions or injuries. In the event that a student experiences an adverse reaction or injury as a result of the mandated HPV vaccine, liability and compensation mechanisms must be in place to address these situations [ 51 ]. Jurisdictions that have implemented school-entry mandates for vaccines often have established vaccine injury compensation programs.…”

Section: Reviewmentioning

confidence: 99%

Implementing a School-Entry Mandate for the Human Papillomavirus Vaccine: Benefits and Challenges

Alzahrani

2024

Cureus

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Human papillomavirus (HPV), a common sexually transmitted infection, has prompted the development of vaccines to mitigate associated cancer risks, particularly cervical cancer. Regions that have achieved a high rate of vaccination coverage are witnessing a transformative impact on public health, with a notable reduction of up to 30% in the incidence of cervical cancer cases. Emphasizing the broader impact of vaccination on public health, this review investigates the role of a school-entry mandate for the HPV vaccine, aiming to inform decisions about its potential benefits and challenges. With a focus on understanding the significance of vaccination, the review delves into its potential to reduce the physical, emotional, and financial burdens associated with HPV-associated cancers. Implementing school-entry mandates for the HPV vaccine offers benefits such as increased vaccination rates, protection against HPV-related diseases, and long-term health advantages. However, challenges include ethical concerns, parental opposition, and logistical issues. Successful implementation requires clear communication, collaboration, and education, with legal and ethical considerations addressing constitutional rights, liability concerns, autonomy, and equitable access. In summary, the implementation of school-entry mandates for the HPV vaccine offers the potential for increased vaccination rates and the reduction of health disparities. However, this approach is challenged by factors such as opposition, associated costs, and legal and ethical considerations. The decision to mandate the HPV vaccine requires a delicate balance between public health priorities and individual rights, necessitating clear communication, education, and collaborative efforts to address the complexities involved.

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Compensation programs after withdrawal of the recommendation for HPV vaccine in Japan

Cited by 6 publications

References 6 publications

Encouraging Cross-Disciplinary Collaboration and Innovation in Epidemiology in Japan

Encouraging Cross-Disciplinary Collaboration and Innovation in Epidemiology in Japan

A Genetically Modified attenuated Listeria Vaccine Expressing HPV16 E7 Kill Tumor Cells in Direct and Antigen-Specific Manner

Implementing a School-Entry Mandate for the Human Papillomavirus Vaccine: Benefits and Challenges

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