Compensation of Vestibular Lesions

Schaefer, K. P.; Meyer, Dietrich

doi:10.1007/978-3-642-65920-1_13

Cited by 206 publications

(44 citation statements)

References 87 publications

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“…In addition, gravity receptors of the vestibular system control movements of the eyes (vestibuloocular reflexes) (Cohen, 1974). In aquatic animals, modification of the vestibular input either by vestibular lesions or by a transient deprivation (exposure to weightlessness during spaceflights) leads to profound depression of the reflexes (Schaefer and Meyer, 1974) [for amphibians (cf. Agosti et al, 1986;Rohregger and Dieringer, 2002;Horn et al, 1986b;Horn, 2006)].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it resembled movements recorded from Xenopus tadpoles immediately after a spaceflight (Horn, 2006;Horn and Gabriel, 2011) rather than those recorded from aquatic animals with unilateral utricular lesions [cf. Schaefer and Meyer, 1974; for Xenopus tadpoles (Rayer et al, 1983)]. …”

Section: Swimmingmentioning

confidence: 99%

“…Based on observations in animals with unilateral vestibular lesions (Schaefer and Meyer, 1974;Rayer et al, 1983), spinning movements should be expected in XTcf-4 morphants. Instead, looping swimming was dominant in these morphants, which resembled tadpole swimming recorded after spaceflights (Horn and Gabriel, 2011 (Tay and Straznicky, 1980).…”

Section: Neurobiological Aspectsmentioning

confidence: 99%

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The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4

Horn

El-Yamany

Gradl

2012

Journal of Experimental Biology

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Section: Discussionmentioning

confidence: 99%

Section: Swimmingmentioning

confidence: 99%

Section: Neurobiological Aspectsmentioning

confidence: 99%

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The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4

Horn

El-Yamany

Gradl

2012

Journal of Experimental Biology

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“…The successful maintenance of an upright posture is thought to be dependent on reflexes arising from the labyrinth as well as proprioceptors in the neck, since destruction of either labyrinth input (e.g. Schaefer & Meyer, 1974) or neck afferent input (Cohen, 1961) leads to similar postural instabilities. Under normal circumstances, the action of the labyrinth and neck reflexes on the same limb are opposed (Rosenberg & Lindsay, 1973;Lindsay et al 1976).…”

Section: Discussionmentioning

confidence: 99%

The effect of cerebellectomy on the tonic labyrinth and neck reflexes in the decerebrate cat.

Dutia¹,

Lindsay²,

Rosenberg³

1981

The Journal of Physiology

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SUMMARY1. Tonic labyrinth and neck reflexes were studied separately and in combination in the decerebrate cat before and after acute cerebellectomy. Reflex effects were observed as changes in the length of the medial head of triceps in both forelimbs.2. In the decerebrate cat with an intact cerebellum the tonic labyrinth reflexes, elicited by side-up and side-down head rotations, produced asymmetric length changes in the medial head of triceps in both forelimbs, as described by Lindsay, Roberts & Rosenberg (1976). After cerebellectomy, head movements in either direction produced reflex shortenings in the medial triceps in both forelimbs, in contrast to the normal reciprocal reflex length changes. The presence of the cerebellum is thus required for the occurence of the normal asymmetric labyrinth reflexes.3. The direction of the neck reflexes remained unchanged by cerebellectomy. 4. It is suggested that the postural disturbances following cerebellar damage may partly result from the change in the form of the tonic labyrinth reflexes, which in combination with the tonic neck reflexes would no longer act in a stabilizing manner on the trunk.

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“…The main behavioral consequence of this unilateral vestibular removal is a postural imbalance from which the animals can recover over time. Therefore, this model has been used in various species to study functional recovery and its possible physiological determinants (Schaefer & Meyer, 1974;Dieringer, 1995;Deliagina, 1997;Vidal et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

2000

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SUMMARYIn this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were testednamely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK-801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion of the right labyrinth, the animals (n=12) were treated intraperitoneally daily either with vehicle (n=12), substance P (n=ll),

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Compensation of Vestibular Lesions

Cited by 206 publications

References 87 publications

The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4

The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4

The effect of cerebellectomy on the tonic labyrinth and neck reflexes in the decerebrate cat.

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

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