Compatible solutes: Thermodynamic properties relevant for effective protection against osmotic stress

Held, Christoph; Sadowski, Gabriele

doi:10.1016/j.fluid.2015.07.004

Cited by 45 publications

(24 citation statements)

References 52 publications

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“…The density of the concentrated juices was reduced due to the decrease in the concentration and the increase in the temperature [ 34 ]. Those parameters (concentration and density) might have an influence on the value of the osmotic pressure [ 35 , 36 ]. The viscosity of the OS significantly decreases at the beginning of osmotic dehydration process, depending on the temperature and concentration of the concentrated juice.…”

Section: Resultsmentioning

confidence: 99%

The Influence of the Osmotic Dehydration Process on Physicochemical Properties of Osmotic Solution

et al. 2017

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The osmotic dehydration (OD) process consists of the removal of water from a material during which the solids from the osmotic solution are transported to the material by osmosis. This process is commonly performed in sucrose and salt solutions. Taking into account that a relatively high consumption of those substances might have a negative effect on human health, attempts have been made to search for alternatives that can be used for osmotic dehydration. One of these is an application of chokeberry juice with proven beneficial properties to human health. This study aimed to evaluate the physicochemical properties of the OD solution (chokeberry juice concentrate) before and after the osmotic dehydration of carrot and zucchini. The total polyphenolics content, antioxidant capacity (ABTS, FRAP), dynamic viscosity, density, and water activity were examined in relation to the juice concentration used for the osmotic solution before and after the OD process. During the osmotic dehydration process, the concentration of the chokeberry juice decreased. Compounds with lower molecular weight and lower antioxidant capacity present in concentrated chokeberry juice had a stronger influence on the exchange of compounds during the OD process in carrot and zucchini. The water activity of the osmotic solution increased after the osmotic dehydration process. It was concluded that the osmotic solution after the OD process might be successfully re-used as a product with high quality for i.e. juice production.

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Section: Resultsmentioning

confidence: 99%

The Influence of the Osmotic Dehydration Process on Physicochemical Properties of Osmotic Solution

et al. 2017

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“…Most commonly,p ure-component parameters are fitted to densitieso rp hase equilibria of pure fluids (e.g., [289] ), while solubility data can be used to adjustb inary parameters (e.g., [290] ). More recently,p ure-component parameters of reacting agents of enzymatic reactions as well as binary parameters have been adjusted to experimental osmoticp ressure data of binary solutions [291][292][293] and to experimental solubility data. [290] Al arge variety of equations of state has been appliedt oc orrelate activity coefficients of amino acids and oligopeptides in water,w hich neglect the non-spherical shape of the biomolecules.…”

Section: Effect Of Cosolvents On Enzymatic Reactions and The Importanmentioning

confidence: 99%

“…[294][295][296] To overcome this limitation, modelsh ave been developed that account also for the non-spherical shapes of molecules, and include repulsive interactions as well as dispersive, associative (hydrogen bonds), polar,a nd ionic interactions, such as the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). [289] PC-SAFT has been used to predict activityc oefficients of biomolecules in aqueous multi-component solutionsc ontaining cosolutes such as amino acids, [273,291,297,298] salts, [299][300][301][302] osmolytes, [293,299] organic solvents, [292,300] and sugars. [292] The availability of such predictive thermodynamic models is an important step towards 1. determining the activity-based valueso fK a M and K th according to Equations (14) and (15), and 2. the use of K a M and K th to predict the equilibrium position and reaction rates at different solutionc onditions by accounting for activity coefficients.…”

Section: Effect Of Cosolvents On Enzymatic Reactions and The Importanmentioning

confidence: 99%

Crowders and Cosolvents—Major Contributors to the Cellular Milieu and Efficient Means to Counteract Environmental Stresses

et al. 2017

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The free energy and conformational landscape of biomolecular systems as well as biochemical reactions depend not only on temperature and pressure, but also on the particular solution conditions. Such conditions include the effects of cosolvents (for example osmolytes) and macromolecular crowding, which are crucial components to understand the energetics and kinetics of biological processes in living system. Such conditions are also important for the understanding of many debilitating diseases, such as those where misfolding and amyloid formation of proteins are involved. Moreover, understanding their effects on biomolecular processes is prerequisite for designing industrially relevant enzymatic reactions, which seldom take place under neat conditions. Here, we review and discuss experimental and theoretical studies on the characterization of cosolvent and crowding induced effects in biologically relevant systems, approaching even the complexity of living organisms. In particular, we focus on cosolvent and crowding effects on the conformational equilibrium and folding kinetics of proteins and nucleic acids as well as on enzymatic reactions, including their effects on the temperature and pressure dependence of these processes. By presenting a few representative examples, we show how such effects are unveiled and described in thermodynamic and kinetic terms.

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“…Dashed lines are predictions from the universal quasi‐chemical functional group activity coefficient (UNIFAC) group contribution method . Panel c) shows the practical activity coefficient of TMAO in aqueous solution as function of TMAO molality from experiment , and various force fields suggested over the last years . Simulation results were obtained with thermodynamic integration .…”

Section: Some Aspects Of Force Field Validationmentioning

confidence: 99%

Insights into Noncovalent Binding Obtained from Molecular Dynamics Simulations

Baz

Gebhardt

Kraus

et al. 2018

Chemie Ingenieur Technik

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The key to nanoscale control of physical, chemical, and biological processes lies in well‐founded models of noncovalent binding. Atomistic simulations probe the free‐energy surface underlying molecular assembly processes in solution. Two examples of noncovalent binding studied by molecular dynamics simulations are discussed, the dimerization of a water‐soluble perylene bisimide derivative in aqueous solution with a focus on the influence of solvent composition on the aggregation strength and the binding of 1‐butanol to α‐cyclodextrin at infinite dilution with the focus on the determination of method‐independent binding free energies.

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Compatible solutes: Thermodynamic properties relevant for effective protection against osmotic stress

Cited by 45 publications

References 52 publications

The Influence of the Osmotic Dehydration Process on Physicochemical Properties of Osmotic Solution

The Influence of the Osmotic Dehydration Process on Physicochemical Properties of Osmotic Solution

Crowders and Cosolvents—Major Contributors to the Cellular Milieu and Efficient Means to Counteract Environmental Stresses

Insights into Noncovalent Binding Obtained from Molecular Dynamics Simulations

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