Compatibility study of hydroxypropylmethylcellulose films containing zidovudine and lamivudine using thermal analysis and infrared spectroscopy

Porfírio, Leandro de O.; Costa, Adjane A.; Conceição, Rosane R.; Matos, Thamara de O.; Almeida, Ellen Denise Prado; Sarmento, Víctor Hugo Vitorino; Araújo, Adriano A. S.; Nunes, Rogéria de Souza; Lira, Ana Amélia Moreira

doi:10.1007/s10973-014-3938-5

Cited by 14 publications

(6 citation statements)

References 36 publications

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“…2). The DSC curves of HPMC, MCC, PVP and CCS show one thermal event at 58.30, 59.75, 68.20 and, 62.39 °C, respectively, corresponding to the dehydration and over 250 °C starts their thermal decomposition (Porfírio et al, 2015, Pereira et al, 2014). The LAC curve demonstrates three endothermic events related to dehydration (144.38 °C), melting point (216.11 °C), and thermal decomposition (240.31 °C), respectively (Pereira et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

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Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

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Rosmarinic acid (RA) is a phenolic compound that presents well-documented anti-inflammatory, antioxidant and antitumor activities, and based on its pharmacological potential and poor bioavailability, several solid dosage forms have been developed to RA delivery. Therefore, in literature, there are no reports about RA compatibility with excipients. In this regard, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms at a 1:1 (RA:excipient) ratio using differential scanning calorimetry (DSC), thermogravimetry (TG), Fourier-transform infrared (FTIR), solid-state nuclear magnetic resonance (ssNMR), and isothermal stress testing (IST) coupled with liquid chromatography (LC). The excipients selected were hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), lactose monohydrate (LAC), polyvinylpyrrolidone (PVP), talc (TALC), croscarmellose sodium (CCS), and magnesium stearate (MgSTE). According to DSC results, physical interactions were found between RA and HPMC, LAC, CCS, and MgSTE. The TG analyses confirmed the physical interactions and suggested chemical incompatibility. FTIR revealed physical interaction of RA with TALC and MgSTE and the ssNMR confirmed the physical interaction showed by FTIR and excluded the presence of chemical incompatibility. By IST, the greatest loss of RA content was found to CCS and MgSTE (>15%), demonstrating chemical incompatibilities with RA. High temperatures used in DSC and TG analyses could be responsible for incompatibilities in binary mixtures (BMs) with HPMC and LAC, while temperature above 25 °C and presence of water were factors that promote incompatibilities in BMs with CCS and MgSTE. Overall results demonstrate that RA was compatible with MCC and PVP.

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Section: Resultsmentioning

confidence: 99%

“…The decomposition events of each excipient are described in Fig. S2 and Table S2 Supplementary Material (Porfírio et al, 2015, Pereira et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Veras

Fachel

Pittol

et al. 2019

Saudi Pharmaceutical Journal

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“…The exothermal peak temperature of the decomposition of BDNPA/F is shifted forward about 1.9°C in CTTHV/BDNPA/F mixture, falling in ‘A' rating. The gravimetric peak temperatures can be used for probing the compatibility, which avoids the obstacle aroused by the overlapping exothermal processes during the thermal decomposition of polymers 16,34,35 . The gravimetric peak temperature of CTTHV in the third stage is suitable to evaluate the effects of BDNPA/F on CTTHV, because the first and second stages of the thermal decomposition of CTTHV are overlapping with the BDNPA/F decomposition process.…”

Section: Resultsmentioning

confidence: 99%

“…According to the Figure 2B, the thermal weight loss peak temperatures of those stages are 365, 525°C respectively. The indivisible exothermal decomposition processes 16,34,35 of FO elastomer form a distinct exothermic peak near 379°C on the DSC curve of FO elastomer. After adding energetic plasticizer BDNPA/F into FO elastomer, it could easily be found that the initial thermal decomposition temperature of FO/BDNPA/F elastomers, compared with that of FO elastomer, is advanced by about 50 to 75°C as shown in Figure 2A, which can be attributed to the decomposition of BDNPA/F 16–18 .…”

Section: Resultsmentioning

confidence: 99%

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Investigation on the thermal decomposition of the elastomer containing fluoroolefin segment by DSC‐TG‐MS‐FTIR

Tang

Zeng

et al. 2021

Polymers for Advanced Techs

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Based on the cross-linking reaction of bisphenol A epoxy resin and liquid carboxyterminated poly(tetrafluoroethylene-hexafluoropropylene-vinylidene fluoride) copolymer (CTTHV), the elastomer containing fluoroolefin segment was prepared. The bis (2,2-dinitropropyl)-acetal/formal (BDNPA/F) was used as an energetic plasticizer for this fluoroolefin segment-containing elastomer (FO elastomer). The compatibility of CTTHV and BDNPA/F was evaluated by the combination of differential scanning calorimetry (DSC) and derivative thermogravimetry (DTG) methods. Thermal decomposition of the FO elastomers was investigated by TG-DSC. The kinetic parameters of the FO elastomers were calculated by Kissinger-Akahira-Sunose method. DSC-TG-MS-Fourier transform infrared spectroscopy analysis was used to detect the thermal decomposition products. The thermal decomposition mechanisms of the FO and FO/BDNPA/F elastomers were discussed. The results show that CTTHV has a good compatibility with BDNPA/F, and the prepared FO/BDNPA/F elastomers have good thermal stability. BDNPA/F can promote the thermal decomposition of the FO elastomer and bring more heat for the binder system according to the thermal decomposition behaviors and kinetic calculation results of FO/BDNPA/F elastomers. The FO elastomer preferentially undergoes depolymerization, HF elimination with the formation of polyene sequences, and subsequent main-chain cleavage, polyaromatization. The H ion fragments of the decomposition of BDNPA/F can be an important factor in the improvement of HF concentration at the initial thermal decomposition of FO elastomer. An abundant HF released during all decomposition of FO/BDNPA/F elastomers may be beneficial to the ignition and combustion of aluminum particles in future applications.

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Effect of fast neutrons on the structure and thermal properties of PVA/HPMC blends

Abdel-Zaher

Moselhey²,

Guirguis

2016

J Therm Anal Calorim

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Compatibility study of hydroxypropylmethylcellulose films containing zidovudine and lamivudine using thermal analysis and infrared spectroscopy

Cited by 14 publications

References 36 publications

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques

Investigation on the thermal decomposition of the elastomer containing fluoroolefin segment by DSC‐TG‐MS‐FTIR

Effect of fast neutrons on the structure and thermal properties of PVA/HPMC blends

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