Compatibility study <i>In-vitro</i> drug release Study of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System for Rasagiline Mesylate

Wake, Prashant S.; Kshirsagar, M. D.

doi:10.5958/2231-5659.2017.00014.5

Cited by 10 publications

(4 citation statements)

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“…The percentage loading of drug was increased by increasing the ratio of polymer as found high in all the formulation. Encapsulation ef iciency is the amount of drug entrapped within a colloidal system after a formulation process (Wake and Kshirsagar, 2017). Better drug loading was achieved by increasing the ratio of polymer.…”

Section: Resultsmentioning

confidence: 99%

Polysaccharide-Based Controlled Release Systems for Antipsychotic Therapeutics Delivery

Srivastava¹,

Tripathi²

2020

ijrps

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Researches in pharmaceutical fields are now focusing on biopolymer-based drug delivery systems for treatment of mild to severe diseases. Amongst all biopolymers, pectin is one of the frequently available and eco-friendly bio-polymer extracted from different fruit peels and abundantly available in nature. This study focuses to extract the pectin from two different fruits using different methods namely hot water-based extraction and cold maceration, involving two different fruit peels. Post extraction and isolation of polymer, study was performed for characterization of pectin powder by particle shape, particle size distribution, surface area angle of repose, flowability and tapped density. The obtained pectin was used for anti-psychotic drug delivery when incorporated into microspheres by solvent evaporation method. It’s surface morphology and release kinetics was analyzed using in vitro methods and in vivo models and kinetics of drug release (goodness of fit) was assessed. The result revealed that the pectin extracted from mango peel using soxhlation method showed good flow rate, minimum particle size and shape distribution, porosity etc. Moreover, it showed the better drug release data in both invitro and in-vivo analysis. The study concludes that in future the natural biopolymer like pectin stands as a potential candidate for formulation of drug release system for efficient delivery of drug

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Section: Resultsmentioning

confidence: 99%

Polysaccharide-Based Controlled Release Systems for Antipsychotic Therapeutics Delivery

Srivastava¹,

Tripathi²

2020

ijrps

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“…RP-SLN and RP-NLC formulations were stored in 20 ml scintillation glass vails while RP-SLN-C and RP-NLC-C hydrogels were filled in aluminum collapsible tubes. Samples were withdrawn from RP-SLN and RP-NLC formulations at predetermined time intervals and analyzed for physical parameters such as PS, PDI, ZP, % EE, and assay while RP-SLN-C and RP-NLC-C formulations were observed for the change in pH, viscosity, spreadability, extrudability, and % drug content 28,46 .…”

Section: Stability Studiesmentioning

confidence: 99%

“…Furthermore, these lipid nanoparticles showed occlusive properties as a result of film formation on the skin, which reduces transdermal water loss and also favored the drug penetration into the skin . Moreover, SLN and NLC containing hydrogels have been reported for the enhanced skin penetration of various drugs such as triptolide, flurbiprofen, and RP [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Preparation, In Vitro characterization and stability studies of ropinirole lipid nanoparticles enriched hydrogel for treatment of neurodegeneration diseases

Samanthula¹,

Alli²,

Gorre³

2021

J. Drug Delivery Ther.

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Ropinirole (RP), is a selective dopamine agonist that is used alone or with other medications to treat the symptoms of Parkinson’s disease (PD). RP has low bioavailability of only about 50% due to the first-pass metabolism, and it requires frequent dosing during oral administration. The objective of the current research was to develop RP loaded solid lipid nanoparticles (RP-SLNs), nanostructured lipid carriers (RP-NLCs), and their corresponding hydrogels (RP-SLN-C and RP-NLC-C) that might improve efficacy in PD treatment. RP nanoparticles were prepared by homogenization aided probe sonication method and optimized based on particle size, polydispersity index (PDI), zeta potential (ZP), assay, entrapment efficiency, and in vitro release studies. Optimized formulations were converted to hydrogel formulations using Carbopol 934 as a gelling polymer and optimized based on rheological and release characteristics. Optimized formulations were further evaluated using differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), scanning electron microscopy (SEM), freeze-drying, and stability study at refrigerated and room temperatures. The optimized RP-SLN formulation showed particle size and entrapment efficiency of 213.5±3.8 nm and 77.9±3.1% compared to 190.6±3.7 nm and 85.7±1.7% for optimized RP-NLC formulation. PXRD supplemented and confirmed DSC results, RP was entrapped in a molecularly dispersed state inside the core of the lipid nanocarrier. Furthermore, RP loaded lipid nanocarriers revealed a spherical shape in SEM images. In vitro release studies demonstrated sustained release profiles for RP from SLNs, NLCs, and their hydrogels over 24 h and were stable over three months at 4ºC and 25ºC storage conditions. Keywords: Parkinson’s disease, Ropinirole, Solid lipid nanoparticles, Nanostructured lipid carriers, Hydrogel.

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“…Some interesting results have been published by Gaur et al [110], who studied SLNs loaded with curcumin and obtained high drug permeation through human skin after 24h by including ceramide-2 in the formulation. The amounts and the proportions of components may also influence the SLN properties as shown by Wake et al [111], who designed SLNs for transdermal rasagiline mesylate to alleviate the symptoms of Parkinson's disease. This research has shown that increasing the concentration of stearic acid in the SLNs led to a higher entrapment while increasing the concentration of tween 80 led to a smaller particle size.…”

Section: Mes Pnp and Ln As Nanocarriers For Transdermal Drug Delivermentioning

confidence: 99%

Microemulsions and Nanoparticles as Carriers for Dermal and Transdermal Drug Delivery

2019

J Pharmacol Pharm Res

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Compatibility study In-vitro drug release Study of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System for Rasagiline Mesylate

Cited by 10 publications

References 0 publications

Polysaccharide-Based Controlled Release Systems for Antipsychotic Therapeutics Delivery

Polysaccharide-Based Controlled Release Systems for Antipsychotic Therapeutics Delivery

Preparation, In Vitro characterization and stability studies of ropinirole lipid nanoparticles enriched hydrogel for treatment of neurodegeneration diseases

Microemulsions and Nanoparticles as Carriers for Dermal and Transdermal Drug Delivery

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