Compatibility, Kidney Paired Donation, and Incompatible Living Donor Transplants

Garg, Neetika; Gill, Jagbir; Mandelbrot, Didier A.

doi:10.1007/978-3-030-53618-3_10

Cited by 1 publication

(1 citation statement)

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“…10 Development of KPD programs for patients with willing but biologically incompatible donors has been an important advance in expanding opportunities for LDKT. 11 Using algorithms to exchange kidneys among 2 or more donor-recipient pairs, KPD programs create compatible combinations that address blood group and donor-specific alloreactivity incompatibilities. Nondirected donors (ie, donors who do not have an identified recipient) provide the unique potential to expand the donor pool through chains of kidney exchanges.…”

Section: Introductionmentioning

confidence: 99%

A Roadmap for Innovation to Advance Transplant Access and Outcomes: A Position Statement From the National Kidney Foundation

Lentine

Pastan

Mohan

et al. 2021

American Journal of Kidney Diseases

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Over the past 65 years, kidney transplantation has evolved into the optimal treatment for patients with kidney failure, dramatically reducing suffering through improved survival and quality of life. However, access to transplant is still limited by organ supply, opportunities for transplant are inequitably distributed, and lifelong transplant survival remains elusive. To address these persistent needs, the National Kidney Foundation convened an expert panel to define an agenda for future research. The key priorities identified by the panel center on the needs to develop and evaluate strategies to expand living donation, improve waitlist management and transplant readiness, maximize use of available deceased donor organs, and extend allograft longevity. Strategies targeting the critical goal of decreasing organ discard that warrant research investment include educating patients and clinicians about potential benefits of accepting nonstandard organs, use of novel organ assessment technologies and real-time decision support, and approaches to preserve and resuscitate allografts before implantation. The development of personalized strategies to reduce the burden of lifelong immunosuppression and support "one transplant for life" was also identified as a vital priority. The panel noted the specific goal of improving transplant access and graft survival for children with kidney failure. This ambitious agenda will focus research investment to promote greater equity and efficiency in access to transplantation, and help sustain long-term benefits of the gift of life for more patients in need.As this article reflects the official position of the National Kidney Foundation (NKF) and because it was reviewed and approved by NKF, it was not peer reviewed by AJKD. This article was prepared by a work group comprising the authors and chaired by Dr Krista Lentine. It was reviewed and approved by the NKF Scientific Advisory Board and the NKF Executive Committee.Complete author and article information provided before references.

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Section: Introductionmentioning

confidence: 99%