Compatibility Evaluation of Non-Woven Sheet Composite of Silk Fibroin and Polyurethane in the Wet State

Aytemiz, Derya; Fukuda, Yasuhiro; Higuchi, Akira; Asano, Atsushi; Nakazawa, Chikako T.; Kameda, Tsunenori; Yoshioka, Taiyo; Nakazawa, Yasumoto

doi:10.3390/polym10080874

Cited by 19 publications

(17 citation statements)

References 28 publications

(35 reference statements)

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“…Those patches rendered the Young's modulus in the range of 8–30 MPa. Moreover, the commercially available PTFE patches showed the Young's modulus of 15–20 MPa depending upon the conditions . Our fabricated patch values are matching with those reported findings suggesting its feasibility in cardiac TE.…”

Section: Resultssupporting

confidence: 87%

Electrospun polyurethane patch in combination with cedarwood and cobalt nitrate for cardiac applications

Mani

Jaganathan

Prabhakaran

et al. 2019

J of Applied Polymer Sci

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The growth in nanotechnology led to the fabrication of scaffold at a low cost with high productivity and high surface area. The present research aims to fabricate a novel cardiac scaffold utilizing polyurethane (PU) added with cedarwood (CW) and cobalt nitrate (CoNO 3 ) nanofibers. Morphological analysis showed that the mean fiber diameter of the PU nanofibers was reduced owing to the incorporation of CW and CoNO 3 . Infrared and thermal analysis revealed the interaction of PU with CW and CoNO 3 . Contact angle studies showed that the electrospun PU/CW displayed hydrophobic nature while PU/CW/CoNO 3 showed hydrophilic behavior compared to the pristine PU. The tensile strength of PU nanofibers increased with CW and CoNO 3 addition. Atomic force microscopy analysis depicted that the PU/CW was rougher while the PU/CW/CoNO 3 as smoother surfaces than the pristine PU. According to the coagulation assay data, the blood compatibility of the electrospun composites was enhanced compared to the pristine PU. In addition, PU and its composite nanofibers exhibited non-toxic to human dermal fibroblast cells and improved cell proliferation rates compared to the control plates. To conclude, the improved physicochemical and biological response of the electrospun composites would be putative for cardiac tissue engineering.

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Section: Resultssupporting

confidence: 87%

Electrospun polyurethane patch in combination with cedarwood and cobalt nitrate for cardiac applications

Mani

Jaganathan

Prabhakaran

et al. 2019

J of Applied Polymer Sci

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show abstract

“…In another example, 1:1 SF/poly(L-lactic acid) (PLLA) composite films prepared by electrospinning showed high keratinocytes attachment and proliferation; plus, the material itself showed enhanced mechanical properties [ 7 ]. A novel nonwoven sheet of SF/polyurethane blending for cardiovascular tissue engineering also exhibited good miscibility and feasible mechanical properties [ 8 , 10 ]. These changes in the material properties are closely related to their structure and morphology.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the above-mentioned research focused their applications on electrospun nanofibers at some specific ratio of SF to PLA [ 3 , 5 , 7 , 8 , 10 , 11 , 17 ]. In this work, dual-crystallizable silk fibroin/poly(L-lactic acid) (SF/PLLA) nanocomposite films at different mixing ratios were first-time obtained by using a new physical blending method.…”

Section: Introductionmentioning

confidence: 99%

Dual-Crystallizable Silk Fibroin/Poly(L-lactic Acid) Biocomposite Films: Effect of Polymer Phases on Protein Structures in Protein-Polymer Blends

Wang

Gough

et al. 2021

IJMS

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Biopolymer composites based on silk fibroin have shown widespread potential due to their brilliant applications in tissue engineering, medicine and bioelectronics. In our present work, biocomposite nanofilms with different special topologies were obtained through blending silk fibroin with crystallizable poly(L-lactic acid) (PLLA) at various mixture rates using a stirring-reflux condensation blending method. The microstructure, phase components, and miscibility of the blended films were studied through thermal analysis in combination with Fourier-transform infrared spectroscopy and Raman analysis. X-ray diffraction and scanning electron microscope were also used for advanced structural analysis. Furthermore, their conformation transition, interaction mechanism, and thermal stability were also discussed. The results showed that the hydrogen bonds and hydrophobic interactions existed between silk fibroin (SF) and PLLA polymer chains in the blended films. The secondary structures of silk fibroin and phase components of PLLA in composites vary at different ratios of silk to PLLA. The β-sheet content increased with the increase of the silk fibroin content, while the glass transition temperature was raised mainly due to the rigid amorphous phase presence in the blended system. This results in an increase in thermal stability in blended films compared to the pure silk fibroin films. This study provided detailed insights into the influence of synthetic polymer phases (crystalline, rigid amorphous, and mobile amorphous) on protein secondary structures through blending, which has direct applications on the design and fabrication of novel protein–synthetic polymer composites for the biomedical and green chemistry fields.

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“…In addition, PEO has shown high versatility as a carrier polymer. Therefore, a combination of controlled fiber diameters and specific protein loading such as silk fibroin may support tissue regeneration [15]. Building upon evidence that silk fibroin promotes tissue regeneration, recent approaches have studied its potential as a coating for implants [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Silk Fibroin on Cell Viability in Electrospun Scaffolds of Polyethylene Oxide

et al. 2019

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In this study, a coating from electrospun silk fibroin was performed with the aim to modify the surface of breast implants. We evaluated the effect of fibroin on polymeric matrices of poly (ethylene oxide) (PEO) to enhance cell viability, adhesion, and proliferation of HaCaT human keratinocytes to enhance the healing process on breast prosthesis implantation. We electrospun six blends of fibroin and PEO at different concentrations. These scaffolds were characterized by scanning electron microscopy, contact angle measurements, ATR-FTIR spectroscopy, and X-ray diffraction. We obtained diverse network conformations at different combinations to examine the regulation of cell adhesion and proliferation by modifying the microstructure of the matrix to be applied as a potential scaffold for coating breast implants. The key contribution of this work is the solution it provides to enhance the healing process on prosthesis implantation considering that the use of these PEO–fibroin scaffolds reduced (p < 0.05) the amount of pyknotic nuclei. Therefore, viability of HaCaT human keratinocytes on PEO–fibroin matrices was significantly improved (p < 0.001). These findings provide a rational strategy to coat breast implants improving biocompatibility.

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Compatibility Evaluation of Non-Woven Sheet Composite of Silk Fibroin and Polyurethane in the Wet State

Cited by 19 publications

References 28 publications

Electrospun polyurethane patch in combination with cedarwood and cobalt nitrate for cardiac applications

Electrospun polyurethane patch in combination with cedarwood and cobalt nitrate for cardiac applications

Dual-Crystallizable Silk Fibroin/Poly(L-lactic Acid) Biocomposite Films: Effect of Polymer Phases on Protein Structures in Protein-Polymer Blends

Effect of Silk Fibroin on Cell Viability in Electrospun Scaffolds of Polyethylene Oxide

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