Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

Silva, Ihatanderson A.; Lima, Ana Luiza; Gelfuso, Guilherme M.; Barreto, Lívia Cristina Lira de Sá; Cunha-Filho, Marcílio

doi:10.1016/j.jpha.2021.09.010

Cited by 16 publications

(12 citation statements)

References 49 publications

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“…The melting peak of the drug-loaded filament appeared at 53.5 °C, which is 4 degrees lower than that of pure PCL and placebo. The absence of the drug-melting peak can be explained on the basis of drug crystals completely solubilized into the polymer matrix when processed with HME, creating a solid amorphous dispersion [ 40 ]. Another possible reason is that the PVP-VA has a degradation temperature of approximately 220 °C; thus, the degradation curve masked the drug melting temperature [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

Ebrahimi

Gong

et al. 2023

Pharmaceutics

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Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusion to mass produce drug products, but making tailored solid dosage forms with this technology is neither cost-effective nor simple. This study explored the use of a combination of fused filament fabrication and injection molding to create patient-specific solid dosage forms. A tablet fixation and location template was used to overprint directly on injection-molded tablet bases, and theophylline was combined with polycaprolactone and Kollidon® VA64 via hot-melt extrusion to produce the filament. Dynamic mechanical analysis was used to evaluate the brittleness of the filament, and differential scanning calorimetry was used to analyze the thermal results. The results showed that theophylline had a flow promoting effect on the polymer blend and that overprinted tablets were manufactured faster than 3D-printed tablets. Drug release studies also showed that overprinted tablets released faster than injection-molded tablets. This method demonstrates the potential of hybrid manufacturing for the pharmaceutical industry as a means of bridging the gap between personalized dosage forms and mass production.

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Section: Resultsmentioning

confidence: 99%

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

Ebrahimi

Gong

et al. 2023

Pharmaceutics

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“…Laser-based writing includes stereolithography (SLA) and selective laser sintering (SLS). The type of ink and critical parameters to control differ from each other [ 25 , 26 , 27 , 28 , 29 ].…”

Section: 3d Printing Of Medicinesmentioning

confidence: 99%

3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals

et al. 2023

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3D printing technologies enable medicine customization adapted to patients’ needs. There are several 3D printing techniques available, but majority of dosage forms and medical devices are printed using nozzle-based extrusion, laser-writing systems, and powder binder jetting. 3D printing has been demonstrated for a broad range of applications in development and targeting solid, semi-solid, and locally applied or implanted medicines. 3D-printed solid dosage forms allow the combination of one or more drugs within the same solid dosage form to improve patient compliance, facilitate deglutition, tailor the release profile, or fabricate new medicines for which no dosage form is available. Sustained-release 3D-printed implants, stents, and medical devices have been used mainly for joint replacement therapies, medical prostheses, and cardiovascular applications. Locally applied medicines, such as wound dressing, microneedles, and medicated contact lenses, have also been manufactured using 3D printing techniques. The challenge is to select the 3D printing technique most suitable for each application and the type of pharmaceutical ink that should be developed that possesses the required physicochemical and biological performance. The integration of biopharmaceuticals and nanotechnology-based drugs along with 3D printing (“nanoprinting”) brings printed personalized nanomedicines within the most innovative perspectives for the coming years. Continuous manufacturing through the use of 3D-printed microfluidic chips facilitates their translation into clinical practice.

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“…The major disadvantage of FDM is the high processing temperature not suitable for certain temperature sensitive drugs and biologics. Compatibility and stability are two important aspects of tablet evaluation for safety and efficacy ( 14 ). Semisolid extrusion is a 3D printing method carried out at room temperature that produces objects or devices out of gels or pastes.…”

Section: Types Of 3d Printingmentioning

confidence: 99%

3D printing of pharmaceuticals for disease treatment

Chakka

Chede

2023

Front. Med. Technol.

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Three-dimensional (3D) printing or Additive manufacturing has paved the way for developing and manufacturing pharmaceuticals in a personalized manner for patients with high volume and rare diseases. The traditional pharmaceutical manufacturing process involves the utilization of various excipients to facilitate the stages of blending, mixing, pressing, releasing, and packaging. In some cases, these excipients cause serious side effects to the patients. The 3D printing of pharmaceutical manufacturing avoids the need for excessive excipients. The two major components of a 3D printed tablet or dosage form are polymer matrix and drug component alone. Hence the usage of the 3D printed dosage forms for disease treatment will avoid unwanted side effects and provide higher therapeutic efficacy. With respect to the benefits of the 3D printed pharmaceuticals, the present review was constructed by discussing the role of 3D printing in producing formulations of various dosage forms such as fast and slow releasing, buccal delivery, and localized delivery. The dosage forms are polymeric tablets, nanoparticles, scaffolds, and films employed for treating different diseases.

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Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

Cited by 16 publications

References 49 publications

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals

3D printing of pharmaceuticals for disease treatment

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