Compatibility and Stability of Morphine Sulphate and Naloxone Hydrochloride in 0.9% Sodium Chloride for Injection

Kistner, Charlotte; Ensom, Mary H H; Decarie, Diane; Lauder, Gillian; Carr, Roxane

doi:10.4212/cjhp.v66i3.1253

Cited by 4 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MINI-BAG Plus Container System and VIAL-MATE Adaptor have widespread utility across a range of different drugs and therapeutic areas. They are used for the administration not only of drugs that require reconstitution prior to use, 16 , 17 like cefiderocol and other antibiotics, but also ready-to-use products, 18 which can offer favorable safety, reduced waste and, in some cases, economic advantages, and may have particular applications for antimicrobial use in the outpatient setting. The results from this small study support the use of these established systems but should not be extrapolated beyond cefiderocol; the compatibility of other products should be confirmed on an individual basis.…”

Section: Conclusion and Relevancementioning

confidence: 99%

Cefiderocol For Injection: Compatibility Testing Using the MINI-BAG Plus Container System and the VIAL-MATE Adaptor

Rathod,

Chen,

Slover

et al. 2023

Journal of Pharmacy Technology

View full text Add to dashboard Cite

Background: Cost-effective and convenient modalities are required to facilitate the administration of antibiotics in hospital and outpatient settings. Objective: This study investigated the physical compatibility of the MINI-BAG Plus Container System and VIAL-MATE Adaptor with the 1 g drug product vials used for cefiderocol. Methods: Qualitative testing of the MINI-BAG Plus Container System (50 and 100 mL of 5% dextrose injection or 0.9% sodium chloride injection), using empty vials and vials containing lyophilized cefiderocol powder, was conducted in triplicate on MINI-BAGs that were hung and observed over 3 hours. Connection security between empty vials and the VIAL-MATE Adaptor was assessed in triplicate. Results: All predefined physical compatibility criteria between cefiderocol 1 g vials and the MINI-BAG Plus Container System were met, including a secure connection, successful multiple transfers of solution between vial and bag, successful reconstitution of cefiderocol, and lack of leaking into the vial or from the connections. There was no particulate matter in the prepared solution and no precipitation or discoloration. Secure connections between the VIAL-MATE Adaptor and cefiderocol vials were demonstrated. Conclusion and Relevance: Use of these systems is relevant even where resources are limited and may increase the efficiency of cefiderocol administration in hospitals, outpatient settings, or long-term healthcare facilities.

show abstract

Section: Conclusion and Relevancementioning

confidence: 99%

Cefiderocol For Injection: Compatibility Testing Using the MINI-BAG Plus Container System and the VIAL-MATE Adaptor

Rathod,

Chen,

Slover

et al. 2023

Journal of Pharmacy Technology

View full text Add to dashboard Cite

show abstract

“…In this study, the infusion samples were visually inspected with the naked eye for the solution colour and clarity each time, and duplicate pH measurements were conducted. 16 All samples from each test were then aliquoted and frozen at −20°C until further analysis. The samples from each bag and bottle were analysed in triplicate (n=3).…”

Section: Stability Study Of the Analgesic Solutionsmentioning

confidence: 99%

“…28 C. Kistner and others studied the effect of different concentrations and time periods of NH injections mixed with morphine sulphate prepared in 0.9% sodium chloride solutions. 16 They reported that 1000 µg/mL morphine sulphate and NH at concentrations of 4, 12.5, or 25 µg/mL in a 0.9% sodium chloride solution for injection remained stable for 72 h at room temperature and for 30 days under refrigeration. In this experiment, the quantitative analysis methods of FC with NH were adapted from the published literature on chromatographic analysis methods.…”

Section: Dovepressmentioning

confidence: 99%

<p>Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration</p>

Chen

Lei

et al. 2020

DDDT

View full text Add to dashboard Cite

Background and Objective: The combination of naloxone hydrochloride (NH) and fentanyl citrate (FC) in patient-controlled analgesia (PCA) is examined to reduce the risk of opioid-induced nausea and vomiting. However, there are no such commercially available drug mixtures, and there is also no published evidence on the compatibility and stability of NH and FC. Thus, the primary purpose of the current research is to investigate the physical compatibility and chemical stability of NH when mixed with FC over a 72-h period in a 0.9% sodium chloride injection solution for PCA administration under storage at 4°C and 25°C. Methods: Test solutions of 20 μg/mL FC and 4 μg/mL NH were prepared and stored in polyvinyl chloride (PVC) bags or glass bottles with a 0.9% sodium chloride injection solution as the diluent. During the 72-h storage period at 4°C or 25°C without light protection, the concentrations of the test drugs were assayed via high-performance liquid chromatography (HPLC), and the physical compatibility was determined with the naked eye. Furthermore, pH measurement of each sample was also performed with a pH meter. Results: The percentages of the initial concentrations of FC and NH in the various solutions were maintained at a minimum of 98% over the 72-h study period. All of the mixtures remained clear and colourless throughout the observation period, and no precipitation or turbidity was observed in any of the batches. Conclusion: The 20 μg/mL FC test solution was physically compatible and chemically stable with the 4 μg/mL NH test solution when stored at 4°C or 25°C in PVC bags or glass bottles containing the 0.9% sodium chloride injection solution.

show abstract

“…If one takes alcohol beyond the upper limit in a short period of time, the Central Nervous System (CNS) gets excited first and then inhibits the alcohol intake. The sudden change can cause serious damage of the CNS, the liver, and other human organs [2,3]. Immediate treatments can help the patient to get through smoothly the critical period of the disorder and reduce the occurrence of complications.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Gou¹,

Peng²,

Yang³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

Objective: This study aimed to analyse the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism. Methods: A total of 146 patients admitted between August 2015 and August 2017 in the hospital where the author works were divided into control (n=73) and test (n=73) groups using the odd-even method. Routine and naloxene hydrochloride treatments were administered to the control and test groups, respectively. The clinical effects on the two groups were then compared. Results: The overall response rate of the test group was significantly higher (P<0.05) than that of the control group. The test group significantly outperformed the control group in terms of onset, symptom remission, and symptom disappearance times. The two groups were also compared in terms of limbmovement recovery time, the time when GCS rating reaches eight points, and the duration of hospitalization. Similarly, the test group again showed a significantly higher (P<0.05) performance than the control group. Furthermore, the test and control groups were compared in terms of negative response rate, wherein no significant difference (P<0.05) was observed. Conclusions: The use of naloxone hydrochloride in the emergency treatment of acute alcoholism was reliable, effective, and safe. The compound can significantly alleviate the patients' clinical symptoms and shorten the recovery time. Therefore, further clinical application of naloxone hydrochloride should be promoted.

show abstract

Compatibility and Stability of Morphine Sulphate and Naloxone Hydrochloride in 0.9% Sodium Chloride for Injection

Abstract: Background: Naloxone may be administered in conjunction with morphine to reduce the risk of opioid-induced pruritis. Combining these drugs for coadministration may be beneficial, but little is known about their physical compatibility and stability in combined solutions.

Cited by 4 publications

References 33 publications

Cefiderocol For Injection: Compatibility Testing Using the MINI-BAG Plus Container System and the VIAL-MATE Adaptor

Cefiderocol For Injection: Compatibility Testing Using the MINI-BAG Plus Container System and the VIAL-MATE Adaptor

<p>Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration</p>

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Contact Info

Product

Resources

About