Purpose: The purpose of this article is to provide conceptual clarification of secondary traumatic stress (STS) in nurses.Background: As an empathetic helping profession, nurses are at increased risk for STS. Interchangeable usage of related terms among multidisciplinary literature has resulted in lack of conceptual clarity resulting in conflation of terms. Conceptual clarity is necessary for a foundation for further research on treatment.Methods: Rodgers' evolutionary model of concept analysis.Results: Nurses are predisposed to STS due to exposure, empathy, bonding, and personal factors. Essential attributes were found to be posttraumatic stress disorderlike symptoms, biological symptoms, social symptoms, and psychological symptoms.Resultant consequences included an altered worldview, interpersonal difficulties, and decreased occupational commitment.Conclusion: This concept analysis, the first focusing on STS, provides conceptual clarity and a concept map of STS within the nursing population.