Compartment calcium model of frog skeletal muscle during activation

Liu, Weifan; Olson, Sarah D.

doi:10.1016/j.jtbi.2014.08.050

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…Similarly, Novo et al [13] and Groenendaal et al [7] found that the location of the Ca 2+ release site from the SR was an important contributor to the Ca 2+ dynamics during contraction/relaxation cycles. More recently, Liu and Olson [11] developed a model for frog muscle that incorporated voltage sensitivity of Ca 2+ release.…”

Section: Introductionmentioning

confidence: 99%

The sensitivity of fast muscle contractile function to the major components of the sarcomere Ca2+-cycling system

Golding

Kelly

Kinsey

et al. 2016

Biophysical Chemistry

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A reaction–diffusion model of a muscle sarcomere was developed to evaluate the sensitivity of force characteristics to diffusion and Ca2+-cycling components. The model compared well to experimental force measurements. Diffusion led to Ca2+ gradients that enhanced maximal force and accelerated relaxation compared to when diffusion was infinitely fast. However, a modest increase in sarcomere length or radius led to a decrease in maximal force. Lowering the Ca2+ release rate caused a lower maximal force, but increasing the rate led to only modest gains in maximal force while incurring much greater ATP costs associated with reuptake. Greater parvalbumin binding rates decreased maximal force but enhanced relaxation, and this effect was magnified when Ca2+ uptake rates were lowered as may occur during fatigue. These results show a physiological set of parameters that lead to a functional sarcomere of known dimensions and contractile function, and the effects of parameter variation on muscle function.

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Section: Introductionmentioning

confidence: 99%