Abstract:We successfully engineered the CDM network labeled with fluorescent markers highlighting fibronectin -a protein of the extracellular matrix, and we also observed the dynamics of key components driving cell migration, such as the actin cytoskeleton and focal contacts. Our results reveal key differences between 2D and 3D cell migration. (i) We report new types of protrusions distinct from filopodia/lamellipodia reported on planar surfaces, which are driven by pressure. (ii) Our 3D network is deformed reversibly … Show more
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