Comparitive in vitro effects of mono- and polychromatic photodynamic therapy on malignant transformed B- and T-cells

Kaulmann, R.; Rück, Angelika; König, Karsten; Scheffold, W.; Boehncke, W. H.

doi:10.1016/0923-1811(93)91235-m

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“…Various skin precancerous or malignant tumors (actinic keratoses, carcinomas of basal and squamous cells, etc.) have shown partial or complete clinical response to photodynamic treatment. , PDT also has the potential to cure a variety of nonmalignant skin disorders, such as psoriasis, viral infections, or diseases of the epidermal appendages. ,, Various macrocycles have been incorporated into chitosan membranes by adsorption, by dissolution and casting, or by covalent attachment . Water-soluble meso -tetrakis(4-sulfonato-phenyl)porphyrin (TPPS 4 ) (Chart c) could be interesting in this context because of its apparent antitumor activity and its strong affinity toward chitosan.…”

Section: Introductionmentioning

confidence: 99%

Modification of Chitosan–Methylcellulose Composite Films with meso-Tetrakis(4-sulfonatophenyl)porphyrin

et al. 2011

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Polysaccharide films containing chitosan, methylcellulose, and a mixture of these polysaccharides in various ratios were prepared and modified with meso-tetrakis(4-sulfonatophenyl)porphyrin in an aqueous medium at pH 7. The modified films were compared with the initial films using spectroscopic methods and microscopic imaging. Electronic (UV-vis absorption, electronic circular dichroism (ECD)) and vibrational (FTIR and Raman) spectra showed that the porphyrin macrocycles had a strong affinity toward chitosan and did not interact with the methylcellulose. The total porphyrin uptake depended on the chitosan: methylcellulose ratio and pure methylcellulose films did not retain porphyrin macrocycles. ECD measurements detected the presence of optically active porphyrin species bound to the films. SEM and AFM images confirmed that the porphyrin macrocycles caused structural changes on the film surface and within the film layer.

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