Comparisons of the toxicokinetic parameters in rats determined for low and high dose of .GAMMA.-chlordane.

Ohno, Yasuo; Kawanishi, Toru; Takahashi, Atsushi; Nakaura, Shinsuke; Kawashima, Kunio; Tanaka, Satoru; Takanaka, Akira; Omori, Yoshihito; Sekita, Hiroshi; Uchiyama, Mitsuru

doi:10.2131/jts.11.111

Cited by 8 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was not the case with HEP, but early deaths in the highest dose group prevented testing of all rats, and consequently it is not known which effects HEP would have produced in these rats before death occurred. CDN and presumably HEP are eliminated slowly from the body Downloaded by [New York University] at 10:42 05 February 2015 (Barnett & Dorough, 1974;Ohno et al, 1986), which probably contributed to the cumulative toxicity and enhanced effectiveness with repeated dosing.…”

Section: Pesticides: Treatment Effectsmentioning

confidence: 99%

A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity

Moser

Cheek²,

MacPhail

1995

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

The neurobehavioral effects of 10 known toxicants were examined as part of a multidisciplinary screening battery. The toxicants included carbaryl (CAR), triadimefon (TDM), heptachlor (HEP), chlordane (CDN), diethylhexyl phthalate (DEHP), carbon tetrachloride (CCl4), phenol, trichloroethylene (TCE), tetrachloroethylene (PER or perchlorethylene), and dichloromethane (DCM or methylene chloride). A functional observational battery and motor activity measurements were conducted before exposure, at specified times after an acute exposure, and during and after 14-d exposure. Severity scoring analysis was used to generate profiles of effect. The pesticides, CAR, TDM, HEP, and CDN, displayed the most acute neurotoxicity and were active at lower proportions of their respective acute LD50 values than were the solvents or the industrial chemicals. Although CAR and TDM showed little or no neurobehavioral effects with repeated dosing, cumulative neurotoxicity and lethality were evident with HEP and CDN. Phenol produced acute convulsive effects, and the most prominent finding with repeated exposure was lethality. DEHP displayed no neurobehavioral toxicity. The organic solvents, TCE, PER, CCl4, and DCM, produced various degrees of general nervous system depression following acute administration of high dose levels. Repeated dosing produced little or no effect with TCE or PER, marked physiological changes with CCl4, and cumulative toxicity and lethality with DCM. Some results of these studies were unexpected and should provide impetus for further research. Overall, these findings illustrate the utility of these screening methods.

show abstract

Section: Pesticides: Treatment Effectsmentioning

confidence: 99%