Comparisons of the surface micromotions of cementless femoral prosthesis in the horizontal and vertical levels: a network analysis of biomechanical studies

Abstract

Background: Numerous quantitatively biomechanical studies measuring the fixation stability of femoral stem using micromotions at the bone-implant interfaces in different directions and levels remain inconclusive. This network meta-analysis performed systematically aims to explore the rank probability of micromotions at the bone-implant interfaces based on biomechanical data from studies published. Methods: Two electronic databases, PubMed/MEDLINE and Embase, were utilized to retrieve biomechanical studies providing the data of micromotions at the bone-stem interfaces. After screening and diluting out, the studies that met inclusion criteria will be utilized for statistical analysis. In order to contrast the stability of commonness and differences of the different parts of the femoral stem, the horizontal and vertical comparison of micromotions at the bone-implant interfaces were conducted using the pooled evaluation indexes including the mean difference (MD) and the surface under the cumulative ranking (SUCRA) curve, while inconsistency analysis, sensitivity analysis, subgroup analyses, and publication bias were performed for the stability evaluation of outcomes. Results: Screening determined that 20 studies involving a total of 249 samples were deemed viable for inclusion in the network meta-analysis. Tip point registered the highest micromotions of 13 measurement points. In the horizontal level, the arrangements of 4 measurement points at the proximal (P1-P4), middle (P5-P8) and distal part of the stem (P9-P12

The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases

“…38,39 Immune inflammation and overexpression of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) are associated with bone health issues, which have destructive impact on normal bone homeostasis through various mechanisms. 40 Catabolic states associated with immune inflammation and pathological bone loss are exemplified in a range of skeletal disorders, including periprosthetic osteolysis, 3,41 aseptic loosening, 42,43 osteoporosis, and rheumatoid arthritis. These conditions are major contributors to disability and impose a significant financial burden globally (Figure 1).…”

Osteoimmune Interactions and Therapeutic Potential of Macrophage-Derived Small Extracellular Vesicles in Bone-Related Diseases

“…Aseptic loosening is a common complication following total joint arthroplasty due to periprosthetic inflammatory osteolysis and is the leading cause of revision procedures. 88 , 89 Wear particles released from the sliding surfaces of prosthetic materials induce a persistent local inflammatory response, thereby stimulating bone resorbing-osteoclast activities and bone loss around the implant. 90 , 91 Macrophages activated by wear particulate debris release an array of cytokines and proinflammatory mediators in the joint fluid and facilitate the recruitment of inflammatory cells.…”