Comparisons of TBS and lumbar spine BMD in the associations with vertebral fractures according to the T-scores: A cross-sectional observation

Lee, Jie Eun; Kim, Kyoung Min; Kim, Lee Kyung; Kim, Kyong Young; Oh, Tae Jung; Moon, Jae Hoon; Choi, Sung Hee; Lim, Soo; Kim, Sang Wan; Shin, Chan Soo; Jang, Hak Chul

doi:10.1016/j.bone.2017.09.017

Cited by 27 publications

(22 citation statements)

References 36 publications

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“…Indeed, the TBS represents that the bone strength may be useful for assessing the risk of vertebral fractures. e association between low TBS and vertebral fractures, however, was demonstrated in postmenopausal women and men with the chronic obstructive pulmonary disease, and there was no study in thalassemia patients [29][30][31].…”

Section: Discussionmentioning

confidence: 98%

The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand

Teawtrakul

Chukanhom

Charoensri

et al. 2020

Anemia

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Introduction. Thalassemia bone disease is one of the disease-related complications in patients with thalassemia. Prevalence of fractures and the role of a trabecular bone score (TBS) as a predictive factor for fractures were evaluated in patients with thalassemia. Methods. A cross-sectional study was conducted in patients with thalassemia aged ≥18 years at Srinagarind Hospital, Khon Kaen University, Thailand. A lateral thoracolumbar radiograph and bone mineral density (BMD) at the lumbar spine and hip, as well as the TBS measured by dual-energy X-ray absorptiometry (DXA), were evaluated in all patients. Results. Among 86 patients, 14 patients were found to have radiographic vertebral fracture yielding a prevalence of 16.3%. All patients who had fractures were β-thalassemia/Hb E. Combined low BMD and TBS at lumbar spines and a presence of endocrinopathies were significantly associated with vertebral fractures. Conclusions. The prevalence of vertebral fractures in patients with thalassemia was not uncommon. A combined low BMD and TBS and a presence of endocrinopathies were associated with vertebral fractures. These findings suggested that BMD testing and TBS measurement have a clinical implication as a screening tool for evaluating the risk of vertebral fractures in thalassemic patients, particularly in β-thalassemia/Hb E who have endocrinopathies.

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Section: Discussionmentioning

confidence: 98%

The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand

Teawtrakul

Chukanhom

Charoensri

et al. 2020

Anemia

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“…Inconsistent lumbar spine BMD and TBS results were found in individuals with degenerative changes with calcification including osteoarthritis, osteophytes, scoliosis, and aortic calcification, 43,44 where BMD increased in elder patients with calcific degenerative changes, whereas the TBS continuously declined with increasing age regardless of any calcific degeneration. Moreover, a cross‐sectional study 45 showed that decreased TBS was associated with increased odds of having a vertebral fracture in the osteopenia or normal BMD groups. Thus, TBS is an index that can be used independently or combined with BMD in predicting osteoporotic fractures 46‒48 …”

Section: Discussionmentioning

confidence: 99%

Trabecular bone score, a new bone quality index, is associated with severe periodontitis

Niramitchainon

Mongkornkarn

Sritara

et al. 2020

Journal of Periodontology

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Background: The association between systemic bone loss and periodontitis remains unresolved; and the trabecular bone score (TBS) is a new index for assessing decreased bone quality. Therefore, this cross-sectional study investigated the association between TBS and severe periodontitis. Methods: Eight hundred and five Thai participants, aged 30 to 82 years, underwent bone quality assessment. Their mean TBS was calculated from dual-energy X-ray absorptiometry images at the L1 to L4 lumbar spine using TBS software. Each participant was classified as normal, partially degraded, or degraded TBS. Full-mouth periodontal examinations determined plaque score, probing depth, clinical attachment level (CAL), and the number of remaining teeth. The participants were classified as non-severe or severe periodontitis. Differences in periodontal parameters between the TBS groups were analyzed using one-way ANOVA. The association between TBS and severe periodontitis was assessed with multivariate binary logistic regression. For severe periodontitis, the additive interaction between TBS and oral hygiene status was also analyzed. Results: The mean CAL was 0.9-mm higher in the degraded TBS group compared with the normal TBS group. Degraded TBS was associated with severe periodontitis with an adjusted odds ratio (OR) of 2.10 (95% confidence interval [CI] = 1.03 to 4.26). The combination of degraded TBS and plaque score ≥80% increased the adjusted OR to 5.71 (95% CI = 1.15 to 28.43). Conclusions: Degraded TBS is associated with severe periodontitis and has a synergistic effect with poor oral hygiene, suggesting monitoring decreased bone quality and good oral hygiene for promoting the periodontal-systemic health of these individuals.

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“…[35] In particular, the TBS has been shown to be better in identifying in subjects with osteoporotic whose BMDs were normal or osteopenia on DXA with degraded microarchitecture and vertebral fractures. [17]…”

Section: Discussionmentioning

confidence: 99%

“…[16] According to recent study, Recuded TBS has association with increased osteoporotic vertebral fractures risk in patients with osteopenia, as well as in those with normal BMD. [17] In healthy euthyroid post-menopausal women, the TBS is negatively correlated with free thyroxine (fT4) levels within range for high-to-normal. [18] In postmenopausal women with DTC, a longer duration of TSH suppression was independently associated with a decreased lumbar spine TBS.…”

Section: Introductionmentioning

confidence: 99%

Effects of Thyrotropin Suppression on Bone Health in Menopausal Women with Total Thyroidectomy

et al. 2019

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BackgroundThis study examined the change in the trabecular bone score (TBS), areal bone mineral density (aBMD), and osteoporosis in postmenopausal women who underwent thyrotropin (TSH)-suppressive therapy for treating papillary thyroid cancer after a total thyroidectomy procedure.MethodsWe evaluated 36 postmenopausal women who received a total thyroidectomy for papillary thyroid cancer and were undergoing TSH suppressive therapy with levothyroxine. Postmenopausal women (n=94) matched for age and body mass index were recruited as healthy controls. The aBMD and TBS of the lumbar spine were compared between dual energy X-ray absorptiometry (DXA) at baseline and at follow-up after an average of 4.92 years.ResultsThere was no significant difference in the rate of diagnoses of osteoporosis, osteopenia, or normal bone status between the 2 groups during the baseline DXA evaluation. However, the TBS was significantly lower whereas aBMD did not show significant difference at the time of baseline DXA measurement (1st DXA, 1.343±0.098 vs. 1.372±0.06317, P<0.001; 2nd DXA, 1.342±0.095 vs. 1.370±0.062, P<0.001). The TBS and aBMD did not differ significantly between the initial and follow-up DXA images in both groups of TSH suppressive patients and controls.ConclusionsThe average value of TBS and aBMD did not significantly change during the follow-up period. The TSH suppressive therapy was revealed as not a significant factor for the progressive deterioration of bone status during long term follow-up.

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Comparisons of TBS and lumbar spine BMD in the associations with vertebral fractures according to the T-scores: A cross-sectional observation

Cited by 27 publications

References 36 publications

The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand

The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand

Trabecular bone score, a new bone quality index, is associated with severe periodontitis

Effects of Thyrotropin Suppression on Bone Health in Menopausal Women with Total Thyroidectomy

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