Comparisons of responses by planarian to micromolar to attomolar dosages of morphine or naloxone and/or weak pulsed magnetic fields: Revealing receptor subtype affinities and non-specific effects

Abstract

The results support the presence of at least two receptor subtypes that mediate the diminished activity effects elicited by morphine specifically and suggests that exposure to the specifically patterned magnetic field produces a behavioral suppression whose magnitude is similar to the 'dose independent' effects from this opiate.

Validating New Technologies to Treat Depression, Pain and the Feeling of Sentient Beings: A Reply to “Neuroscience for the Soul”

“…There is no doubt that the weak magnetic fields that elicit the sensed presence and reduce depression and relieve pain in human volunteers and patients also produce significant behavioral effects in non-human subjects which are presumably not prone to placebo responding. In addition to the powerful, duration dependent, "dose-dependent", and pattern-specific analgesic effects demonstrated for rats [31], planarian [73], and inferred from the behaviours of human subjects [74] while being exposed to these magnetic fields in our laboratories, comparable changes have been reported and replicated by many other research groups. Similar changes as well as receptor and pharmacological mechanisms have been shown for decades by Alex Thomas [75] and his colleagues.…”

LORETA indicates frequency-specific suppressions of current sources within the cerebrums of blindfolded subjects from patterns of blue light flashes applied over the skull

“…The onset of light emissions for each of the pairs of LEDs was controlled by the frequency-modulated ("Thomas") pattern by a laptop computer. Its temporal configuration has been published several times [3,16]. It is composed of 839 points with values between 0 and 256 which are transformed to voltages between − 5 and + 5.…”

“…"Physiologically patterned" refers to those complex temporal sequences that are similar to those generated by cerebral tissue rather than symmetrical, sinusoidal, or square-wave signatures generated by traditional electronic devices. Similarly patterned magnetic fields have been shown to affect the nociceptive thresholds for rodents [2] and planarians [3] and to influence signaling pathways within malignant cells [4]. Irregularly patterned magnetic fields can be "sensed" by cells.…”

Sensitivity of Planaria to Weak, Patterned Electric Current and the Subsequent Correlative Interactions with Fluctuations in the Intensity of the Magnetic Field of Earth

“…The field used is called Thomas, patterned after a chirp in a communication system [17] ( Figure 1). This pattern was created through the Arduino-microcontroller output system, which translated points to a potential difference between +/− 5 V. The duration of each point was set to 3 ms (milliseconds), and the delay between the end of one cycle through the pattern and the beginning of another was also set to 3 ms.…”