Weaning is the process of decreasing ventilator support and allowing patients to assume a greater proportion of their spontaneous ventilation with the gradual reduction of ventilator support (1). In order to predict the patients' success in maintaining their spontaneous breathing and oxygenation, some parameters have been researched. Among these, the rapid shallow breathing index (RSBI) is the most studied and most accepted system with the highest predictive value (2, 3).Rapid shallow breathing index, the ratio of respiratory rate to tidal volume (f/VT), was first described by Yang and Tobin in 1990, as a parameter for weaning and extubation. A RSBI greater than 105 means that the patient is not ready for weaning off the ventilator (4). Moreover, a RSBI of less than 100-105 has yielded a sensitivity of 97% and a specificity of 65% for predicting weaning success (3). The evaluation of RSBI is valuable during T-tube ventilation; and in clinical practice it is not always possible to perform this assessment.In the present study, we aimed to estimate the patients' readiness toward weaning and to determine the pressure combination that is best compatible with the RSBI calculated by the original method, in which the measurement was done during no ventilator support.
METHODS
Patient PopulationIn this self-controlled and prospective study, the patients mechanically ventilated in an intensive care unit (ICU) were included in the study. The diagnosis of the patients and the underlying etiologies of their mechanical ventilation (MV) need were recorded. Ventilators were calibrated prior to intubation and then appropriate mechanical ventilator settings were done according to each patient's need. All the patients' age, gender, comorbid diseases, smoking history, diagnosis of intubation, intubation and extubation days, weaning trial day, weaning success, length of hospitalization, length of MV and ICU stay, need for re-intubation, outcome (exitus or discharge to home/ ward), and causes of mortality were recorded.