Comparisons of Positron Emission Tomography/Computed Tomography and Ultrasound Imaging for Detection of Internal Mammary Lymph Node Metastases in Patients With Breast Cancer and Pathologic Correlation by Ultrasound‐Guided Biopsy Procedures

An, Yeong Yi; Kim, Sung Hun; Kang, Bong Joo; Lee, Ah Won

doi:10.7863/ultra.34.8.1385

Cited by 18 publications

(12 citation statements)

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“…Previous studies have demonstrated that PET/CT is superior to conventional diagnostic techniques for detection of internal mammary LN metastases [ 21 22 ]. An et al [ 7 ] reported that PET/CT-positive internal mammary LNs were defined as those with an uptake greater than the adjacent background activity of the pectoralis muscle or the intercostal space along the lateral sternal border. In their study, there were statistically significant differences in maximum standardized uptake values from PET/CT between the metastatic and benign IMLN groups ( p =0.002), the mean maximum standardized uptake value of metastatic and benign IMLNs being 3.53±1.79 and 1.06±1.09, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…If pathologic examination was not performed, benign IMLNs were defined as showing 1 year of stability on MRI or no fluorodeoxyglucose (FDG) uptake on positron emission tomography computed tomography (PET/CT) (n=18). In contrast, malignant IMLNs were defined as showing FDG uptake greater than that of the adjacent background activity (determined in regions such as the pectoralis muscle, the intercostal space along the lateral sternal border or the mediastinal blood pool), increased FDG uptake on follow up PET/CT, an increased in size during the follow-up period, or a decrease in size after chemotherapy or radiation treatment (n=31) [ 7 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…Recent evidence indicates that ultrasound imaging (US)-guided core-needle biopsy or fine-needle aspiration performed on suspicious IMLN metastases could yield a high success rate without serious complications [ 7 ]. Although mammography, US, and magnetic resonance imaging (MRI) are used for breast imaging, the optimal imaging modalities or diagnostic criteria for detection of IMLN metastasis have not been established [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Breast Magnetic Resonance Imaging for Assessment of Internal Mammary Lymph Node Status in Breast Cancer

Lee

Kim

2016

J Breast Cancer

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PurposeThe purpose of this study was to assess magnetic resonance imaging (MRI) features of malignant internal mammary lymph nodes (IMLNs) and benign IMLNs in breast cancer patients.MethodsFrom 2009 to 2014, the records of 85 patients with IMLNs were archived using MRI report data; 26 patients with small size (long axis diameter <5 mm) nodes were subsequently excluded. The current study evaluated internal mammary lymph nodes in 59 patients who underwent breast MRI for breast cancer staging and for posttherapy follow-up. All MRI findings were retrospectively evaluated. Malignancy was determined based on pathologic examination and positron emission tomography computed tomography findings. Independent t-tests, Mann-Whitney U tests, chi-square tests, and receiver operating characteristics (ROC) curve analysis were used.ResultsAmong MRI features, there were statistically significant differences between benign and malignant IMLN groups, in short axis length (3.6±1.3 vs. 8.2±2.9 mm, respectively), long axis length (8.1±2.4 vs. 14.5±4.8 mm, respectively), short/long axis ratio (0.45±0.10 vs. 0.59±0.17, respectively), absent fatty hilum (mean, 0% vs. 95%, respectively), and restricted diffusion (15.8% vs. 85.0%, respectively) (p<0.050). Multiplicity and location of intercostal spaces was not different between the two groups. Short axis length was the most discriminative variable for predicting metastatic nodes (area under the ROC curve, 0.951; threshold, 4 mm; sensitivity, 92.5%; specificity, 84.2%).ConclusionConventional MRI and diffusion-weighted MRI are helpful to detect metastasis of internal mammary lymph nodes in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Breast Magnetic Resonance Imaging for Assessment of Internal Mammary Lymph Node Status in Breast Cancer

Lee

Kim

2016

J Breast Cancer

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“…One research showed that the sensitivity of detecting the metastasis of internal mammary lymph nodes in breast cancer was 96.7%, while 92.9% in CEUS and PET/CT, respectively [20]. CEUS could present lymph nodes images as well as PET/CT in regional lymph nodes of lymphoma patients [21]. In addition, CEUS has the advantage of being inexpensive and nonradioactive.…”

Section: Discussionmentioning

confidence: 99%

Application of Contrast-Enhanced Ultrasound (CEUS) in Lymphomatous Lymph Nodes: A Comparison between PET/CT and Contrast-Enhanced CT

Ling

Xia

et al. 2019

Contrast Media & Molecular Imaging

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Purpose. We described imaging characteristics of different types of lymphomas using contrast-enhanced ultrasound (CEUS) and summarized some simple criteria to distinguish between normal lymph nodes and lymphomatous lymph nodes for clinical diagnosis. Materials and methods. Sixty-one lymphoma patients from 2014 to 2015 with 140 suspicious lymph nodes, who had been confirmed by histology and underwent chemotherapy, were enrolled in our study. The responses to chemotherapy were recorded by PET/CT, contrast-enhanced CT, or CEUS. Results. We summarized the CEUS enhancement patterns as two types when detecting lymphomatous lymph nodes, which could be the specific diagnostic criteria: (1) rapid well-distributed hyperenhancement, with 83.1% lesions exhibiting a fast-in hyperenhancement pattern in the arterial phase, and (2) rapid heterogeneous hyperenhancement, with 16.9% lesions exhibiting heterogeneous in the arterial phase. Particularly, we found that all the suspicious lesions of indolent lymphomas were rapid well-distributed hyperenhancement. CEUS successfully identified 117 lymphomatous lymph nodes, while PET/CT and contrast-enhanced CT detected 124 and 113 lymphomatous lymph nodes, respectively. CEUS had an accuracy of 83.57%, and the accuracy of PET/CT and contrast-enhanced CT was 88.57% and 80.71%, respectively (p=0.188). The false-negative rate was 16.43%, 11.43%, and 19.29%, respectively (p=0.188). Conclusion. CEUS could be a useful tool in detecting lymphomatous nodes. A rapid well-distributed hyperenhancement pattern in CEUS could be a useful diagnostic criterion in both aggressive lymphoma and indolent lymphoma. These results can help us distinguish between lymphomatous and benign lymph nodes and make better diagnostic and therapeutic decisions.

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“…Local recurrence can be detected by patients themselves, surgeons, or follow‐up using ultrasound (US) or other imaging techniques, 7,8 Ultrasound and US‐guided fine‐needle aspiration biopsy and core biopsy are valuable for the assessment of both palpable and clinically occult recurrent BCa in autogenous myocutaneous flap breast reconstructions 9,10 . However, fine‐needle aspiration biopsy could give false‐negative results, and not all patients can receive biopsy because of substantial complications, including local hemorrhage, surrounding tissue injury, local infection, and needle tract metastasis, although such complications are uncommon 11 …”

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confidence: 99%

Ultrasound May Help Detect Chest Wall Recurrence After Mastectomy at an Early Stage

Wang

Liu

2020

J of Ultrasound Medicine

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Objectives-To define ultrasound (US) features that help diagnose local recurrence (LR) and differentiate benign masses from LR chest wall masses after mastectomy in patients with breast cancer. Methods-The US and surgical records of 119 pathologically confirmed chest wall masses in 101 patients were reviewed from 4634 patients with breast cancer who underwent mastectomies. The chest wall masses were divided into 2 groups depending on their longitudinal diameter (LD; ≤10 and > 10 mm). The US features of the subgroups, depending on their nature (benign and LR), were analyzed and compared. Results-Among 119 masses, 58 (48.74%) were benign masses, and 61 (51.26%) were LR masses. For LR, the mean area under the curve AE SD, sensitivity, and specificity of US were 0.849 AE 0.033, 85.25%, and 84.48% (P < .001), respectively. Among the US characteristics, vascularity, an irregular shape, and a location in deep layers were the top 3 factors related to LR (odds ratios, 4.0, 2.6, and 2.2). To diagnose LR by US, judging the anatomic layer of the locations of masses with an LD of 10 mm or less and the presence of vascularity in masses with an LD of greater than 10 mm were helpful. Conclusions-Ultrasound is a relatively accurate and objective method to differentiate LR from a benign mass after mastectomy with follow-up. Judging the anatomic layer of the mass location with US likely increases the accuracy of LR diagnosis at an early stage.

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Comparisons of Positron Emission Tomography/Computed Tomography and Ultrasound Imaging for Detection of Internal Mammary Lymph Node Metastases in Patients With Breast Cancer and Pathologic Correlation by Ultrasound‐Guided Biopsy Procedures

Cited by 18 publications

References 23 publications

Breast Magnetic Resonance Imaging for Assessment of Internal Mammary Lymph Node Status in Breast Cancer

Breast Magnetic Resonance Imaging for Assessment of Internal Mammary Lymph Node Status in Breast Cancer

Application of Contrast-Enhanced Ultrasound (CEUS) in Lymphomatous Lymph Nodes: A Comparison between PET/CT and Contrast-Enhanced CT

Ultrasound May Help Detect Chest Wall Recurrence After Mastectomy at an Early Stage

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