Comparisons of periodontal regenerative therapies: A meta‐analysis on the long‐term efficacy

Abstract

Compared with FO, periodontal regeneration surgeries achieved greater PPD reduction and gain in CAL after 1 year, and its effects may last for 5-10 years.

Strontium enhances proliferation and osteogenic behavior of periodontal ligament cells in vitro

“…Periodontitis is an inflammatory disease that progressively damages the periodontium, including alveolar bone, periodontal ligament (PDL), and root cementum . The desire to develop more favorable treatment options to restore the periodontal structure and regain its physiological function has inspired advanced research into periodontal tissue engineering .…”

“…Periodontitis is an inflammatory disease that progressively damages the periodontium, including alveolar bone, periodontal ligament (PDL), and root cementum . The desire to develop more favorable treatment options to restore the periodontal structure and regain its physiological function has inspired advanced research into periodontal tissue engineering . Regenerative periodontal therapy can be used to improve the short‐ and long‐term clinical outcomes of periodontally compromised teeth presenting with deep pockets and reduced periodontal support .…”

Influence of autogenous platelet concentrate on combined GTR/graft therapy in intra‐bony defects: A 13‐year follow‐up of a randomized controlled clinical split‐mouth study

“…The present study investigated the long‐term healing outcomes 13 years after combined GTR/graft therapy with or without additional application of autogenous platelet concentrate. In general, studies reporting on long‐term outcomes after regenerative periodontal therapies are scarce (Wu et al., ). To date, there are only five prospective randomized clinical trials on GTR or combined GTR/graft therapy in intra‐bony defects with follow‐up for 10 years (Nickles, Ratka‐Krüger, Neukranz, Raetzke, & Eickholz, ; Nygaard‐Østby, Bakke, Nesdal, Susin, & Wikesjö, ; Pretzl, Kim, Holle, & Eickholz, ; Pretzl et al., ; Sculean, Kiss, et al., ) and only one very recent study on GTR with a longer observation period (i.e.…”

“…Furthermore, Wu et al. recently concluded in their systematic review on the long‐term efficacy of periodontal regenerative therapy that there is still an urgent need for more long‐term data (Wu, Lin, Song, Su, & Tu, ).…”

“…To the best of our knowledge, there has been no study so far investigating the long-term results of more than 7 years following combined GTR/graft therapy with additional application of APC. Furthermore, Wu et al recently concluded in their systematic review on the long-term efficacy of periodontal regenerative therapy that there is still an urgent need for more long-term data (Wu, Lin, Song, Su, & Tu, 2017).…”