2017
DOI: 10.1038/s41598-017-02622-2
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Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension

Abstract: Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the r… Show more

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Cited by 12 publications
(10 citation statements)
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“…All patients and controls were imaged by a Retinal Vessel Analyzer (RVA) by positioning the subject in front of a non-midriatic camera (TopconTRC-NV2000) to obtain a retinographic image (45°). The images were then processed by IMEDOS software measuring the caliber of vessels emerging from the optic disc, as previously described 37 . In particular, the RVA produces continuous and automated analysis of the vessels combined with correction for small eye movements.…”
Section: Methodsmentioning
confidence: 99%
“…All patients and controls were imaged by a Retinal Vessel Analyzer (RVA) by positioning the subject in front of a non-midriatic camera (TopconTRC-NV2000) to obtain a retinographic image (45°). The images were then processed by IMEDOS software measuring the caliber of vessels emerging from the optic disc, as previously described 37 . In particular, the RVA produces continuous and automated analysis of the vessels combined with correction for small eye movements.…”
Section: Methodsmentioning
confidence: 99%
“…Nongenetic forms of HA are often treated surgically but chronic oral mineralocorticoid receptor (MR) antagonism, generally with spironolactone, has also been used to lower BP . It is believed that the end‐organ damage profile in patients with HA is more severe than essential hypertension, including increased prevalence of cerebral hemorrhage, myocardial infarction, left ventricular hypertrophy, cardiac fibrosis, increased arterial stiffness, microalbuminuria, and microcirculatory wall‐to‐lumen ratio . Attribution of HA‐associated target organ damage, however, is universally confounded by the effects of aging as well as the duration and degree of BP elevation (BP burden) .…”
Section: Introductionmentioning
confidence: 99%
“…The question of the effect of aldosterone on intrarenal hemodynamics in patients with primary aldosteronism is important. Changes in the state of intrarenal hemodynamics are due not only to the effect of arterial pressure in this category of patients, but also directly to aldosterone [4,5,6].…”
mentioning
confidence: 98%