Comparisons of Immunoglobulin Secretion in the Salivary and Mammary Glands of Sheep

Watson, D. J.; Lascelles, A. K.

doi:10.1038/icb.1973.23

Cited by 15 publications

(5 citation statements)

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“…Thus the work of Watson & Lascelles (1973b) suggests marked similarities in immunoglobulin secretion between the salivary and mammary glands of ruminants. It seems that the quantitative difference in IgA secretion is closely related to the level of local antigenic stimulation (cf.…”

Section: A Salivary Immunoglobulinsmentioning

confidence: 99%

“…An attempt to determine the relative importance of the secretory IgA system and the selective transport of Igd into secretion from sheep salivary glands was made recently by Watson & Lascelles (1973b). Parotid saliva was collected from sheep in which an indwelling cannula was inserted into one parotid duct and non-parotid saliva was collected from the buccal cavity of the same sheep after ligation of the non-cannulated parotid duct.…”

Section: A Salivary Immunoglobulinsmentioning

confidence: 99%

“…Secretion .serum ratios' for IgG j and IgA, relative to those for in parotid saliva, non-parotid saliva and milk whey collected from immunized and non-immunized glands of primiparous ewes. (Data fromWatson & Lascelles 1973b) …”

mentioning

confidence: 99%

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Localized Humoral Immunity with Particular Reference to Ruminants

Lascelles

McDowell

1974

Immunological Reviews

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Section: A Salivary Immunoglobulinsmentioning

confidence: 99%

Section: A Salivary Immunoglobulinsmentioning

confidence: 99%

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Localized Humoral Immunity with Particular Reference to Ruminants

Lascelles

McDowell

1974

Immunological Reviews

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“…The predominance of IgCi in mammary secretion, especially in colostrum, is due to a selective mechanism of transfer vk'ithin the glandular epithelium which is capable of distinguishing between the two sub-classes of IgC. In contrast, most of the IgA and IgM in the mammary secretion of the ruminant is synthesized locally by cells of the lymphocyte-plasma cell series situated close to the glandular epithelium (Watson and Lascelles, 1973).…”

Section: Introductionmentioning

confidence: 99%

The Origin of Immunoglobulins in Intestinal Secretion of Sheep

Husband

Lascelles

1974

Aust J Exp Biol Med

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Summary. Studies were made on the origin and mechanism of transfer of IgGj, IgG.,, IgA and IgM into the secretion of isolated loops of jejunum of unanaesthetized sheep. IgA was the major immunoglobulin in intestinal secretion, although considerable quantities of IgGj and IgG^ were also present. Secretion: serum radioactivity ratios for IgGj^ and igG^ were similar, indicating that they were transferred into intestinal secretion with equal facility. Specific radioactivities of the various immunoglobulins in serum and secretion were compared and the results suggested that all the IgGg and most of the IgGj were derived from blood plasma, whereas only a trivial amount of the IgA was plasma-derived. The slow equilibration of IgM, together with its relatively short biological 'half-life', prevented accurate assessment of plasma contribution of this immunoglobulin.INTRODUCTION.

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“…Thus, the ruminant mammary gland which has acquired a highly developed capacity to selectively transfer IgGj has a relatively poorly developed secretory IgA system. However, the IgA system in sheep and cattle seems to be highly developed in other external secretory organs such as the salivary glands (Pahud and Mach, 1970;Mach and Pahud, 1971;Watson and Lascelles, 1971;1973a). On this basis it has been suggested that there is an inverse relationship between the capacity to selectively transfer IgGi and the development of the secretory IgA system (Mach and Pahud, 1971).…”

Section: Introductionmentioning

confidence: 99%

The Origin of Immunoglobulins in Salivary Secretion of Sheep

Lascelles

1976

Aust J Exp Biol Med

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Summary. A comparative study was made on the secretion of IgGj and IgA into parotid and submaxillary saliva of sheep. The purpose of the study was to examine the suggestion that in the external secretory organs of ruminants there is an inverse relationship between the capacity to selectively transfer IgGj^ and the development of the IgA secretory system. Despite a marked difference in the secretion of IgA between the parotid and submaxillary salivary glands, the magnitude of selective transfer of IgGj^ was similar. Thus, there appears to be no relationship between the selective transfer of IgGj^ and the secretion of IgA into the saliva of sheep.

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Comparisons of Immunoglobulin Secretion in the Salivary and Mammary Glands of Sheep

Cited by 15 publications

References 2 publications

Localized Humoral Immunity with Particular Reference to Ruminants

Localized Humoral Immunity with Particular Reference to Ruminants

The Origin of Immunoglobulins in Intestinal Secretion of Sheep

The Origin of Immunoglobulins in Salivary Secretion of Sheep

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