Comparison with Pharmacokinetic Characteristics of Aconitines after Compatibility with Fuzi and Ginseng

Wei, Xu-Ya; Chen, Ze-Yan; Qiu, Zi-Dong; Tan, Ting; Feng, Yulin; Huang, Luqi; Lai, Chang-Jiang-Sheng

doi:10.2139/ssrn.3892711

SSRN Journal

2021

DOI: 10.2139/ssrn.3892711

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Comparison with Pharmacokinetic Characteristics of Aconitines after Compatibility with Fuzi and Ginseng

Xu-Ya Wei

Ze-Yan Chen

Zi-Dong Qiu

et al.

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2024

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“…ALRP is mainly used in clinical practice in the form of processed decoction pieces that enhance efficacy and reduce toxicity. 13,[19][20][21][22] The processed products of ALRP include Heishunpian (HSP), Baifupian, Danfupian, Paofupian, Zhengfupian, Chaofupian, etc. These decoction pieces have reduced toxicity and are used for different clinical indications through compatibility.…”

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confidence: 99%

Research on quality marker based on the processing from Aconiti lateralis radix praeparata to Heishunpian

Xue,

Zhang,

Mei

et al. 2024

Phytochemical Analysis

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IntroductionAconiti lateralis radix praeparata (ALRP), the sub root of Aconitum carmichaelii Debx., is a traditional Chinese medicine with good pharmacological effects. Heishunpian (HSP), prepared through the process of brine immersing, boiling, rinsing, dyeing, and steaming ALRP is one of the most widely used forms of decoction pieces in clinical practice.ObjectivesThis study aims to investigate the mechanisms of component changes and transformations during the processing from ALRP to HSP, and to screen for their quality markers through UHPLC‐QTOF‐MS analysis.MethodsSamples from ALRP to HSP during processing were prepared and analyzed by UHPLC‐QTOF‐MS. By comparing the differences between before and after each processing step, the purpose of processing and the transformation of components during processing were studied. In addition, multiple batches of ALRP and HSP were determined, and potential quality markers were screened.ResultsThrough the analysis of ALRP and five key processing samples, 55 components were identified. Immersing in brine, rinsing, and dyeing were the main factors of component loss, and boiling caused a slight loss of components. Some components were enhanced during the steaming process. Combining the screened differences components between multiple ALRP and HSP, 10 components were considered as potential quality biomarkers.ConclusionThis study found that the adjacent hydroxyl groups of the ester group may have a positive impact on the hydrolysis of the ester group, and 10 quality markers were preliminarily screened. It provides a reference for quality control and clinical application of ALRP and HSP.

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confidence: 99%

Research on quality marker based on the processing from Aconiti lateralis radix praeparata to Heishunpian

Xue,

Zhang,

Mei

et al. 2024

Phytochemical Analysis

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Comparison with Pharmacokinetic Characteristics of Aconitines after Compatibility with Fuzi and Ginseng

Cited by 1 publication

References 0 publications

Research on quality marker based on the processing from Aconiti lateralis radix praeparata to Heishunpian

Research on quality marker based on the processing from Aconiti lateralis radix praeparata to Heishunpian

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