Comparison the Effects of Oral Tizanidine and Tramadol on Intra- and Post-operative Shivering in Patients Underwent Spinal Anesthesia

Adinehmehr, Leili; Salimi, Sohrab; Majedi, Mohammad Azad; Alizadeh, Ali; Sane, Shahryar

doi:10.4103/abr.abr_54_18

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Our trial showed that oral tramadol was effective in reducing the incidence, frequency, duration and severity of post-spinal shivering and meperidine consumption. In agreement with our results, tramadol was reported to be effective in decreasing the incidence and severity of shivering after spinal or general anaesthesia [ 5 , 25 – 27 ]. Our study results showed that the efficacy of anti-shivering medications greatly varies between its prophylactic and therapeutic uses.…”

Section: Discussionsupporting

confidence: 93%

Effects of oral premedication with tramadol, pregabalin or clonidine on shivering after spinal anaesthesia in patients undergoing hysteroscopic procedures

Gaballah¹,

Abdallah²

2020

ait

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Shivering is a common unpleasant perioperative complication of neuraxial anaesthesia. It has been reported in 40-70% of regionally anaesthetized patients. Shivering is a physiological compensatory response to core hypothermia due to redistribution of heat as a result of vasodilatation from chemical sympathectomy of spinal anaesthesia, exposure to a cool environment, infusion of unwarmed fluids and evaporation from exposed surfaces [1]. During neuraxial anaesthesia, not only is core heat redistributed from the trunk (below the sympathectomy level) to the periphery, but also the thermoregulatory system is significantly impaired due to the inhibited tonic vasoconstriction [2]. Moreover, the shivering threshold is reduced by about 0.5°C during neuraxial anaesthesia [3]. The exposure of the thermosensitive structures within the spinal cord to a cold local anaesthetic is another contributing factor [4].

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Section: Discussionsupporting

confidence: 93%

Effects of oral premedication with tramadol, pregabalin or clonidine on shivering after spinal anaesthesia in patients undergoing hysteroscopic procedures

Gaballah¹,

Abdallah²

2020

ait

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“…In a study conducted by Adinehmehr et al 20 oral tizandine and tramadol were comparable in respect to their effect in decreasing the incidence and intensity of shivering when used prophylactically in patients under spinal anaesthesia which was similar to our study. Mittal et al 21 in 2014 evaluated the effects of dexmedetomidine and tramadol on haemodynamics and shivering after spinal anaesthesia and concluded that tramadol is as effective as dexmedetomidine in reducing shivering rate, nausea and vomiting.…”

Section: Discussionsupporting

confidence: 89%

Use of Oral Tramadol to Prevent Post-anaesthetic Shivering in Patients Undergoing Surgery under Spinal Anaesthesia

Acharya

Dangol

2023

Nep. Med. Coll. J.

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Shivering is a common and distressing problem after spinal anaesthesia which occurs due to heat loss and core to peripheral redistribution of body heat, resulting in reduction of core body temperature. Post anaesthetic shivering has deleterious metabolic and cardiovascular effect which should ideally be prevented by pharmacological methods that are economically and practically feasible in all settings compared to many physical methods. Therefore, this study was conducted using a centrally acting analgesic, oral Tramadol hydrochloride prophylactically for the prevention of perianaesthetic shivering after spinal anaesthesia. This prospective observational study was carried out in 106 patients of ASA I or II, aged 15 to 70 yrs of age undergoing lower limb or lower abdominal surgery under spinal anaesthesia. Postanaesthetic shivering was evaluated during the surgery. Shivering was observed in 11 (10.4%) patients and among them 2 (1.9%) patients had grade 1, 6 (5.7%) patients had grade 2, 2 (1.9%) patients had grade 3 and 1 (0.9%) patients had grade 4 type of shivering. Sedation was observed in 19 (17.9%) patients. The result of this study concluded that oral tramadol is very safe and superior to various drugs studied till date and can be used prophylactically as a part of premedication for the prevention of postanaesthetic shivering in patients undergoing surgery under spinal anaesthesia.

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“…Both drugs were found to be equally effective. 23 In a research conducted by Bozgeyik et al, dexmedetomidine was administered in conjunction with tramadol. Both medications demonstrated equivalent efficacy in the prevention of shivering.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Oral Tramadol vs Tizanidine for Controlling Intraoperative Shivering among Patients undergoing Spinal Anesthesia: A Prospective Comparative Study

Brindha

et al. 2024

IJPQA

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Background: Shivering is one of the most frequent postoperative side effects for patients receiving spinal anesthesia. The frequency of shivering varies but is generally between 40 and 50%. The presence of vasodilatation prior to shivering indicates that shivering among patients sustaining neuraxial anesthesia has been a typical thermoregulation mechanism. This study assessed and compared the efficiency of oral tizanidine and tramadol in lessening shivering intraoperatively among patients sustaining spinal anesthesia for urological procedures. Materials and Methods: The Department of Urology conducted this prospective, randomized comparative study of a tertiary care institute for a six-month period. About 100 patients who underwent spinal anesthesia in the Department of Urology for various procedures were selected into the study and assigned into the groups randomly (50 in each group). Group A included the patients who were given oral tramadol 50 mg for 90 minutes before surgery. Group B included the patients who were given oral tizanidine 4 mg for 90 minutes before surgery. Results: The mean age in the oral tramadol group (Group A) and oral tizanidine group (Group B) are 39.7 and 42.4 years, respectively. The oral tramadol (Group A) comprised 39 males and 11 females. The tizanidine group (Group B) comprised 37 males and 13 females. The oral tramadol group showed greater shivering than the oral tizanidine group. Conclusion: Oral tramadol and oral tizanidine have comparable efficacy to control intraoperative shivering, while oral tizanidine has more sedative effects than oral tramadol.

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Comparison the Effects of Oral Tizanidine and Tramadol on Intra- and Post-operative Shivering in Patients Underwent Spinal Anesthesia

Cited by 4 publications

References 22 publications

Effects of oral premedication with tramadol, pregabalin or clonidine on shivering after spinal anaesthesia in patients undergoing hysteroscopic procedures

Effects of oral premedication with tramadol, pregabalin or clonidine on shivering after spinal anaesthesia in patients undergoing hysteroscopic procedures

Use of Oral Tramadol to Prevent Post-anaesthetic Shivering in Patients Undergoing Surgery under Spinal Anaesthesia

Efficacy of Oral Tramadol vs Tizanidine for Controlling Intraoperative Shivering among Patients undergoing Spinal Anesthesia: A Prospective Comparative Study

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