Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study

Verki, Mohammadreza Maleki; Porozan, Samaneh; Motamed, Hassan; Fahimi, Mohammad Ali; Aryan, Abhishek Kumar

doi:10.1016/j.ajem.2018.08.040

Cited by 15 publications

(3 citation statements)

References 12 publications

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“…In renal pain, 5 double-blind RCTs [ 82 , 83 , 84 , 85 , 86 ] included patients receiving an infusion of 15 mg/kg of Mg sulphate versus NSAIDs (Non-steroidal anti-inflammatory) [ 84 ] or versus a reference treatment (0.1 mg/kg of morphine + 30 mg of ketorolac [ 85 ]); patients receiving 50 mg/kg Mg sulphate during surgery [ 82 ] or 50 mg/kg Mg sulphate during 30 min [ 83 ]; and those receiving 2 cc of Mg sulphate during 15 min [ 86 ] ( n = 453). Among these studies, two RCTs showed the efficacy of Mg on pain reduction using VAS at 30 and 60 min [ 84 , 85 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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Magnesium for Pain Treatment in 2021? State of the Art

et al. 2021

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Background: Magnesium (Mg) is commonly used in clinical practice for acute and chronic pain and has been reported to reduce pain intensity and analgesics consumption in a number of studies. Results are, however, contested. Objectives: This review aims to investigate randomised clinical trials (RCTs) on the effectiveness of Mg treatment on pain and analgesics consumption in situations including post-operative pain, migraine, renal pain, chronic pain, neuropathic pain and fibromyalgia. Results: The literature search identified 81 RCTs (n = 5447 patients) on Mg treatment in pain (50 RCTs in post-operative pain, 18 RCTs in migraine, 5 RCTs in renal pain, 6 RCTs in chronic/neuropathic pain, 2 RCTs in fibromyalgia). Conclusion: The level of evidence for the efficacy of Mg in reducing pain and analgesics consumption is globally modest and studies are not very numerous in chronic pain. A number of gaps have been identified in the literature that need to be addressed especially in methodology, rheumatic disease, and cancer. Additional clinical trials are needed to achieve a sufficient level of evidence and to better optimize the use of Mg for pain and pain comorbidities in order to improve the quality of life of patients who are in pain.

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Section: Resultsmentioning

confidence: 99%

“…NDIn renal pain, 5 double-blind RCTs[82][83][84][85][86] included patients receiving an infusion of 15 mg/kg of Mg sulphate versus NSAIDs (Non-steroidal anti-inflammatory)…”

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confidence: 99%

Magnesium for Pain Treatment in 2021? State of the Art

et al. 2021

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“…Just like opioids, NSAIDs are not innocent either in terms of their adverse effects. Additionally, various agents, such as paracetamol, ketamine, calcium channel blockers, alpha blockers, vasopressin analogues and magnesium sulphate, were used for analgesic management of acute renal colic 3‐5 . In addition to these medical treatments, such regional analgesic techniques as trigger point injection, 6 12th intercostal nerve block, 7 and subcutaneous paravertebral block 8 were also employed.…”

Section: Introductionmentioning

confidence: 99%

Erector spinae plane block vs non‐steroidal anti‐inflammatory drugs for severe renal colic pain: A pilot clinical feasibility study

et al. 2020

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Aim Ultrasound‐guided plane blocks are increasingly used in the multi‐modal analgesic concept for reducing opioid consumption. The present study was conducted to compare the analgesic effect of intravenous non‐steroidal anti‐inflammatory drugs (NSAIDs) and erector spinae plane (ESP) block in renal colic patients. Methods In this prospective randomised study, 40 patients with renal colic pain were randomly assigned into two groups: Group NSAID (n = 20) received an intravenous infusion of 50 mg of dexketoprofen trometamol and Group ESP (n = 20) received ultrasound‐guided ESP block with 30 ml 0.25% bupivacaine at the T8 level. The pain severity of patients was assessed using the visual analogue scale (VAS) at baseline, 5, 15, 30, 45 and 60 minutes after intervention. Opioid consumption, patient satisfaction and side effects were recorded. Results In the ESP group, the VAS scores were significantly lower than the NSAID group at 5, 15, 30, 45 and 60 minutes after the procedure (P < .001). Opioid consumption was significantly higher in the NSAID group compared with the ESP group (10/20 vs 0/20, respectively; P < .001). Patient satisfaction was significantly higher in the ESP group (P < .001). Conclusions ESP block can be an alternative, efficient and safe method for the relief of acute renal colic pain.

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Magnesium Infusion Therapy

Wendahl

Weinstein

2019

Infusion Therapy

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Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study

Cited by 15 publications

References 12 publications

Magnesium for Pain Treatment in 2021? State of the Art

Magnesium for Pain Treatment in 2021? State of the Art

Erector spinae plane block vs non‐steroidal anti‐inflammatory drugs for severe renal colic pain: A pilot clinical feasibility study

Magnesium Infusion Therapy

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