Comparison study on extraction techniques used to assess S‐phenylmercapturic acid as low benzene exposure biomarker based on gas chromatography coupled with mass spectrometry
Abstract:The risk assessment of benzene exposure can be performed based on the analysis of biomarkers in biological monitoring processes. S‐phenylmercapturic acid is a specific benzene biomarker, and its analysis challenges the sensitivity of several analytical methods. The present study aims to develop and standardize an analytic procedure to determine this biomarker through gas chromatography–mass spectrometry, based on different extraction methods, to increase the sensitivity and specificity of the studied analytica… Show more
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