Comparison Study of a Natural Non-Antibiotic Growth Promoter and a Commercial Probiotic on Growth Performance, Immune Response and Biochemical Parameters of Broiler Chicks

Manafi, M.

doi:10.2141/jpsa.0150027

Cited by 31 publications

(24 citation statements)

References 31 publications

(35 reference statements)

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“…Organic acid activity will reduce the total microbial load, but will be particularly effective against E. coli and other acid-intolerant organisms. However, in contrast to the findings in the current study, Manafi (2015) reported that the levels of albumin, globulin, and total protein, and the activities of ALT and GGT, were not affected by NAT or DFM.…”

Section: Discussioncontrasting

confidence: 99%

Assessment of a natural, non-antibiotic blend on performance, blood biochemistry, intestinal microflora, and morphology of broilers challenged with Escherichia coli

et al. 2016

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-The effect of a non-antibiotic growth-promoting component composed of natural phytomolecules, directfed microbials, glucomannan oligosaccharides, and organic acids on the performance, intestinal morphology and microbiology, plasma biochemistry, enzyme activities, visceral organ weights, and immune response of commercial broilers challenged with Escherichia coli was investigated. Three hundred and sixty one-day old male Ross 308 broiler chicks were randomly divided into basal diet (control, CON); control plus 0.5 mL of culture materials containing 10 8 cfu/mL of E. coli (E. coli); control with 400 mg/kg bacitracin methylene disalicylate (an antibiotic growth promoter, AGP); control plus 1000 g/t of feed of a blended mixture of natural feed additives (NAT); combination of E. coli and AGP treatments (E. coli + AGP); or the combination of E. coli and NAT treatments (E. coli + NAT). E. coli injection decreased broiler performance by lowering body weight and increasing feed intake, whereas AGP and NAT treatments improved body weight and the feed efficiency when compared to the other groups. However, feed intake was not affected by treatment. Immune response also improved with the addition of NAT, compared with control. Blood biochemistry parameters were significantly affected by the treatments. Nutrient digestibilities were increased by AGP and NAT supplementation in E. coli-challenged groups. Both AGP and NAT significantly decreased E. coli and coliform numbers in ceca. Ileal villus height was not affected by treatment, but ileal crypt depth and goblet cell counts decreased in the NAT relative to control group. Antibiotic growth promoter was somewhat more effective in improving broiler growth and health characteristics than NAT, but since NAT generally improved broiler performance compared to the control group, it can be alternatively used as an alternative to AGP in commercial broiler production.

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Section: Discussioncontrasting

confidence: 99%

Assessment of a natural, non-antibiotic blend on performance, blood biochemistry, intestinal microflora, and morphology of broilers challenged with Escherichia coli

et al. 2016

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“…Oregano increases the antibody titers against Newcastle disease in broilers due to its antioxidant and antimicrobial properties (Mahboubi & Haghi, 2008). The phenolic compounds thymol and carvacrol present in savory enhances the immune response of broilers (Manafi, 2015).…”

Section: Evaluation Of Anherbal Compound a Commercial Probiotic Andmentioning

confidence: 99%

Evaluation of Anherbal Compound, a Commercial Probiotic, and an Antibiotic Growth Promoter on the Performance, Intestinal Bacterial Population, Antibody Titers, and Morphology of the Jejunum and Ileum of broilers

Mahdi

Manafi

2018

Braz. J. Poult. Sci.

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The current study was conducted to examine the effects of an herbal compound, a probiotic and an antibiotic growth promoter (AGP) on the performance, intestinal bacterial population, antibody titers, and morphology of the jejunum and ileum of broilers. A number of 240 male Ross 308 broilers were distributed into four treatments, with five replicates of 12 bird each. The experimental period was 42 days. Treatments includes: 1) basal diet; 2) basal diet supplemented with an AGP (phospho-flavomycin at 450 mg/kg of diet); 3) basal diet supplemented with a Lactobacillus-containing probiotic (250 mg/kg of diet); and 4) basal diet supplemented with an herbal compound (containing thyme, oregano, chamomile, and peppermint essential oils at 1 g/kg of diet). Body weight (BW) and cumulative feed intake (CFI) were measured weekly. Blood parameters, intestinal morphology, vaccine immunity titers, and intestinal microbial population were measured on day 42. The results showed that probiotic and herbal compound supplementation significantly increased body weight (BW) and decreased feed conversion ratio (FCR) (p<0.05), in comparison with the basal diet. A significant increase in vaccine titers against Avian Influenza, Newcastle disease, and Infectious Bursal Disease were achieved with the treatment with herbal compound supplementation. Herbal compound significantly reduced triglycerides, cholesterol, LDL concentration and ALP, AST and ALT activities and increased the HDL levels in blood serum of chicks (p<0.05). The bacterial load of E. coli, Salmonella and coliforms of the AGP-fed group was significantly lower than those fed the control diet. Significant increases in villus height and decrease in crypt depth and goblet cells were seen in the ileum and jejunum of probiotic-fed broilers (p<0.05). In conclusion, better overall immune status and blood biochemical parameters were obtained with the herbal compound than with the probiotic; however, the performance of broilers fed the probiotic was better than that of the broilers fed the herbal compound and the AGP.

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“…Stressful situations in poultry farms may increase the incidence of gastrointestinal disease, particularly of diarrhea during production period and are likely to cause increased susceptibility to infections in the upper respiratory tract in part to suppress the immune system leading to growth rate deficiencies (Manafi, 2015). Probiotics can prevent illnesses during the laying period, which is one of the priorities for quail farmers to produce healthy eggs, and also to nutritionists, who are interested in minimizing gastrointestinal disorders (Pellegrini et al, 2015).…”

Section: Assessment Of a Probiotic Containing Bacillus Subtilis On Thmentioning

confidence: 99%

Assessment of a probiotic Containing Bacillus Subtilis on the Performance and Gut Health of Laying Japanese Quails (Coturnix Coturnix Japonica)

Manafi

Khalaji

Mahdi

2016

Rev. Bras. Cienc. Avic.

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Keywords Japanese quails, egg production, gut health, immune response. ABStRACtThe present study was carried out to determine the effects of the inclusion of a spore-forming probiotic (Bacillus subtilis) in laying Japanese quail diets as an alternative to growth-promoting antibiotics to help produce healthy eggs and meat. This experiment was conducted as a completely randomized design with three treatments (control, 0.05% bacitracin methylene disalicylate (BMD), or 0.1% Bacillus subtilis) of five replicates of 11 quails each. Feed intake and egg production were recorded daily on cage basis. Body weight was determined at the beginning and end of the trial (36 and 42 weeks). At the end of the experiment (42 weeks), antibodies against Newcastle disease and avian influenza, egg components, Haugh units, eggshell quality and breaking strength, blood parameters, cecal microbial population, villus length, and crypt depth were measured. The dietary inclusion of Bacillus subtilis and BMD significantly (p≤0.05) increased egg production and egg weight; however, eggshell thickness and breaking strength, Haugh units, and eggshell percentages were not affected. The dietary addition of both products significantly (p≤0.05) decreased plasma cholesterol levels and increased LDL levels, as well as antibody levels against Newcastle disease and avian influenza (p≤0.01). In birds fed Bacillus subtilis and BMD, crypt depth was reduced, but villus height and villus to crypt ratio were significantly increased (p≤0.001) compared with those fed the basal diet. Cecal coliforms, E. coli, and Salmonella counts were reduced (p≤0.01) in quails fed the diets containing Bacillus subtilis and BMD compared those quails fed the non-supplemented diet. The results of this study demonstrated that in absence of AGPs, the inclusion of a spore-forming probiotic partially improves the performance of laying quails.

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Comparison Study of a Natural Non-Antibiotic Growth Promoter and a Commercial Probiotic on Growth Performance, Immune Response and Biochemical Parameters of Broiler Chicks

Cited by 31 publications

References 31 publications

Assessment of a natural, non-antibiotic blend on performance, blood biochemistry, intestinal microflora, and morphology of broilers challenged with Escherichia coli

Assessment of a natural, non-antibiotic blend on performance, blood biochemistry, intestinal microflora, and morphology of broilers challenged with Escherichia coli

Evaluation of Anherbal Compound, a Commercial Probiotic, and an Antibiotic Growth Promoter on the Performance, Intestinal Bacterial Population, Antibody Titers, and Morphology of the Jejunum and Ileum of broilers

Assessment of a probiotic Containing Bacillus Subtilis on the Performance and Gut Health of Laying Japanese Quails (Coturnix Coturnix Japonica)

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