Comparison study between multicontrast atherosclerosis characterization (MATCH) and conventional multicontrast MRI of carotid plaque with histology validation

Dai, Yongqiang; Lv, Peng; Lin, Jia Wei; Luo, Rongkui; Líu, Hao; Ji, Aihua; Liu, Hui; Fu, Caixia

doi:10.1002/jmri.25444

Cited by 23 publications

(16 citation statements)

References 21 publications

(40 reference statements)

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“…Third, we did not compare NIRS with other sequences, such as MPRAGE and T2-weighted MR imaging. Newly developed multicontrast atherosclerosis characterization sequences can identify carotid plaque components more precisely [24]. Fourth, NIRS cannot directly identify the amount of plaque calcification; however, high-grade carotid plaque calcification at MLA also influences a long-term morphological outcome [25].…”

Section: Study Limitationsmentioning

confidence: 99%

Lipid Core Burden Index Assessed by Near-Infrared Spectroscopy of Symptomatic Carotid Plaques: Association with Magnetic Resonance T1-Weighted Imaging

Nakagawa¹,

Kotsugi²,

Park³

et al. 2021

Cerebrovasc Dis

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Introduction: Vulnerable plaques are a strong predictor of cerebrovascular ischemic events, and high lipid core plaques (LCPs) are associated with an increased risk of embolic infarcts during carotid artery stenting (CAS). Recent developments in magnetic resonance (MR) plaque imaging have enabled noninvasive assessment of carotid plaque vulnerability, and the lipid component and intraplaque hemorrhage (IPH) are visible as high signal intensity areas on T1-weighted MR images. Recently, catheter-based near-infrared spectroscopy (NIRS) has been shown to accurately distinguish LCPs without IPH. This study aimed to determine whether the results of assessment of high LCPs by catheter-based NIRS correlate with the results of MR plaque imaging. Methods: We recruited 82 consecutive symptomatic carotid artery stenosis patients who were treated with CAS under NIRS and MR plaque assessment. Maximum lipid core burden index (max-LCBI) at minimal luminal areas (MLA), defined as max-LCBIMLA, and max-LCBI for any 4-mm segment in a target lesion, defined as max-LCBIAREA, were assessed by NIRS. Correlations were investigated between max-LCBI and MR T1-weighted plaque signal intensity ratio (T1W-SIR) and MR time-of-flight signal intensity ratio (TOF-SIR) in the same regions as assessed by NIRS. Results: Both T1W-SIRMLA and T1W-SIRAREA were significantly lower in the high LCP group (max-LCBI >504, p < 0.001 for both), while TOF-SIRMLA and TOF-SIRAREA were significantly higher in the high LCP group (p < 0.001 and p = 0.004, respectively). A significant linear correlation was present between max-LCBIMLA and both TIW-SIRMLA and TOF-SIRMLA (r = −0.610 and 0.452, respectively, p < 0.0001 for both). Furthermore, logistic regression analysis revealed that T1W-SIRMLA and TOF-SIRMLA were significantly associated with a high LCP assessed by NIRS (OR, 44.19 and 0.43; 95% CI: 6.55–298.19 and 0.19–0.96; p < 0.001 and = 0.039, respectively). Conclusions: A high LCP assessed by NIRS correlates with the signal intensity ratio of MR imaging in symptomatic patients with unstable carotid plaques.

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Section: Study Limitationsmentioning

confidence: 99%

Lipid Core Burden Index Assessed by Near-Infrared Spectroscopy of Symptomatic Carotid Plaques: Association with Magnetic Resonance T1-Weighted Imaging

Nakagawa¹,

Kotsugi²,

Park³

et al. 2021

Cerebrovasc Dis

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“…The performance of MATCH was not compared to a hyper T 1 w sequence such as MP-RAGE. In the same study, using carotid endarterectomy specimens from 13 patients as a reference, MATCH performed as well as the conventional sequences (TOF, T 1 w, T 2 w) in detecting IPH, LRNC, loose matrix, and calcifications with an acquisition time of only 2 ½ minutes (117). MATCH needs to be validated with histology in larger studies.…”

Section: Mrimentioning

confidence: 90%

PET/MRI of atherosclerosis

Aizaz¹,

Moonen²,

Pol³

et al. 2020

Cardiovasc Diagn Ther

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Myocardial infarction and stroke are the most prevalent global causes of death. Each year 15 million people worldwide die due to myocardial infarction or stroke. Rupture of a vulnerable atherosclerotic plaque is the main underlying cause of stroke and myocardial infarction. Key features of a vulnerable plaque are inflammation, a large lipid-rich necrotic core (LRNC) with a thin or ruptured overlying fibrous cap, and intraplaque hemorrhage (IPH). Noninvasive imaging of these features could have a role in risk stratification of myocardial infarction and stroke and can potentially be utilized for treatment guidance and monitoring. The recent development of hybrid PET/MRI combining the superior soft tissue contrast of MRI with the opportunity to visualize specific plaque features using various radioactive tracers, paves the way for comprehensive plaque imaging. In this review, the use of hybrid PET/MRI for atherosclerotic plaque imaging in carotid and coronary arteries is discussed. The pros and cons of different hybrid PET/MRI systems are reviewed. The challenges in the development of PET/MRI and potential solutions are described. An overview of PET and MRI acquisition techniques for imaging of atherosclerosis including motion correction is provided, followed by a summary of vessel wall imaging PET/MRI studies in patients with carotid and coronary artery disease. Finally, the future of imaging of atherosclerosis with PET/ MRI is discussed.

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“…Traditionally MRI often identifies plaque components depending on a combination of series sequences, such as T1-W imaging, T2-W imaging and TOF. The potential limitations may be considered, including limited spatial coverage and slice resolution, long scan time, and even underlying misregistration between different images [ 135 ].…”

Section: Identification Of Vulnerable Plaques At the Macroscopic Levelmentioning

confidence: 99%

“…A study has proved that compared with traditional multicontrast sequences, MATCH can identify more calcifications with a sensitivity of 100.0%. For other features such as IPH, LRNC and the loose matrix, the two identification methods show the same accuracy [ 135 ]. For identifying thin fibrous caps, MATCH may not be reliable.…”

Section: Identification Of Vulnerable Plaques At the Macroscopic Levelmentioning

confidence: 99%

Identification Markers of Carotid Vulnerable Plaques: An Update

Wang

Luo

2022

Biomolecules

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Vulnerable plaques have been a hot topic in the field of stroke and carotid atherosclerosis. Currently, risk stratification and intervention of carotid plaques are guided by the degree of luminal stenosis. Recently, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. Some classical interventions, such as carotid endarterectomy, significantly reduce the risk of stroke in symptomatic patients with severe carotid stenosis, while for asymptomatic patients, clinically silent plaques with rupture tendency may expose them to the risk of cerebrovascular events. Early identification of vulnerable plaques contributes to lowering the risk of cerebrovascular events. Previously, the identification of vulnerable plaques was commonly based on imaging technologies at the macroscopic level. Recently, some microscopic molecules pertaining to vulnerable plaques have emerged, and could be potential biomarkers or therapeutic targets. This review aimed to update the previous summarization of vulnerable plaques and identify vulnerable plaques at the microscopic and macroscopic levels.

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Comparison study between multicontrast atherosclerosis characterization (MATCH) and conventional multicontrast MRI of carotid plaque with histology validation

Abstract: 1 J. Magn. Reson. Imaging 2017;45:764-770.

Cited by 23 publications

References 21 publications

Lipid Core Burden Index Assessed by Near-Infrared Spectroscopy of Symptomatic Carotid Plaques: Association with Magnetic Resonance T1-Weighted Imaging

Lipid Core Burden Index Assessed by Near-Infrared Spectroscopy of Symptomatic Carotid Plaques: Association with Magnetic Resonance T1-Weighted Imaging

PET/MRI of atherosclerosis

Identification Markers of Carotid Vulnerable Plaques: An Update

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