Comparison of α-linolenate and oleate in lowering activity of lipogenic enzymes in rat liver: Evidence for a greater effect of dietary linolenate independent of food and carbohydrate intake

Musch, K.; Ojakian, M. A.; Williams, M. A.

doi:10.1016/0005-2760(74)90109-x

Cited by 71 publications

(18 citation statements)

References 21 publications

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“…Moreover, the correlation between triglyceridemia and the total activity per liver of ACC and ME supports our hypothesis that the fall in lipogenic enzyme activities could, at least partly, explain the decrease in plasma TG. The activity of fatty acid synthase (FAS), the other major lipogenic enzyme, could also contribute to hypotriglyceridemia, (i) since FAS was highly correlated to liver and serum TG in rats [19] and (ii) substitution of ALA for oleic acid decreased FAS activity in rats [49]. As with LC-PUFA, this decreased activity could originate from an inhibition of lipogenic gene expression by ALA, as described in cultured hepatocytes [20].…”

Section: Triglyceride Metabolismmentioning

confidence: 99%

Dose effect of alpha-linolenic acid on lipid metabolism in the hamster

Morise¹,

Mourot²,

Riottot³

et al. 2005

Reprod. Nutr. Dev.

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-In order to meet dietary requirements, the consumption of α-linolenic acid (ALA, 18:3 n-3) must be promoted. However, its effects on triglyceride (TG) and cholesterol metabolism are still controversial, and may be dose-dependent. The effects of increasing dietary ALA intakes (1%, 10%, 20% and 40% of total FA) were investigated in male hamsters. ALA replaced oleic acid while linoleic and saturated FA were kept constant. Triglyceridemia decreased by 45% in response to 10% dietary ALA and was not affected by higher intakes. It was associated with lower hepatic total activities of acetyl-CoA-carboxylase (up to -29%) and malic enzyme (up to -42%), which were negatively correlated to ALA intake (r 2 = 0.33 and r 2 = 0.38, respectively). Adipose tissue lipogenesis was 2-6 fold lower than in the liver and was not affected by dietary treatment. Substitution of 10% ALA for oleic acid increased cholesterolemia by 15% but, as in TG, higher ALA intakes did not amplify the response. The highest ALA intake (40%) dramatically modified the hepatobiliary metabolism of sterols: cholesterol content fell by 45% in the liver and increased by 28% in the faeces. Besides, faecal bile acids decreased by 61%, and contained more hydrophobic and less secondary bile acids. Thus, replacing 10% oleic acid by ALA is sufficient to exert a beneficial hypotriglyceridemic effect, which may be counteracted by the slight increase in cholesterolemia. Higher intakes did not modify these parameters, but a very high dose resulted in adverse effects on sterol metabolism. α-linolenic acid / oleic acid / lipogenesis / cholesterol / triglyceride / bile acid / hamster

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Section: Triglyceride Metabolismmentioning

confidence: 99%

Dose effect of alpha-linolenic acid on lipid metabolism in the hamster

Morise¹,

Mourot²,

Riottot³

et al. 2005

Reprod. Nutr. Dev.

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“…Similar results, however, have been obtained [2] suggesting that prostaglandin synthesis is not required for the linoleate-induced decrease in the specific activity of hepatic fatty acid synthetase. However, polyunsatu- [13] which can 'also act as a prostaglandin precursor [16], are ~so capable of repressing the activities of hepatic fatty ~cid synthetase and #ucose-6-phosphate dehydrogenase. Although the molecular mechanism whereby polyunsaturated fatty acids regulate lipogenesis is still not clear, it does appear that animals on mixed diets have evolved a mechan,~sm whereby these fatty acids, possibly acting as nmrkers of totM fat intake, can swi*ch off de novo fat synthesis which operates maximally in animals fed high carbohydrates/tow fat diets.…”

Section: Effect Of Indmnethacin On the Activity Of Stearoyl Coa Desatmentioning

confidence: 99%

The control of stearoyl‐CoA desaturase by dietary linoleic acid

Jeffcoat

James

1978

FEBS Letters

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“…When we analyzed other fatty acids, we observed that mice from the COt group showed a significantly higher percentage of linoleic acid (p < 0.001) and lower percentage of oleic acid than mice from the OOt group (p < 0.001). It has been demonstrated that linoleic acid reduces liver lipogenesis when compared with oleic acid [29,30]. Thus, we can propose that the effect of TFA was mitigated by linoleic acid in the COt group but not in the OOt group.…”

Section: Discussionmentioning

confidence: 72%

Effects of <b><i>Trans</i></b>-Fatty Acids on Liver Lipid Metabolism in Mice Fed on Diets Showing Different Fatty Acid Composition

et al. 2013

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Aim: Our aim was to investigate the effects of trans-fatty acids (TFA) on liver lipid metabolism in mice fed on experimental diets rich in either oleic or linoleic acid. Methods: Twenty-two male CF1 mice (22.0 ± 0.1 g) were fed with diets rich in corn oil or olive oil, supplemented or not with TFA (0.75 g TFA/100 g diet), for 4 weeks. Changes in triacylglycerol content, the activity and expression of enzymes involved in lipogenesis and fatty acid oxidation were measured. Results: Supplementation of an olive oil-rich diet with TFA increased liver triacylglycerols, the activity and expression of lipogenic enzymes and sterol regulatory element-binding protein SREBP-1a expression. By contrast, when TFA were added to a corn oil-rich diet, they did not modify these parameters. No significant differences were observed among the experimental groups in the activity and expression of carnitine palmitoyltransferase-Ia, body and liver weights or serum triacylglycerol concentrations. Conclusions: The effect of TFA on liver fat accumulation depends on the dietary fatty acid composition. Steatosis induced by TFA when included in an olive oil diet (but not in a corn oil diet) was associated with an increased lipogenesis but not with a decreased fatty acid oxidation in animals fed on the olive oil diet. This metabolic change is mediated by SREBP-1a but not by SREBP-1c, and seems to be independent of insulin.

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Comparison of α-linolenate and oleate in lowering activity of lipogenic enzymes in rat liver: Evidence for a greater effect of dietary linolenate independent of food and carbohydrate intake

Cited by 71 publications

References 21 publications

Dose effect of alpha-linolenic acid on lipid metabolism in the hamster

Dose effect of alpha-linolenic acid on lipid metabolism in the hamster

The control of stearoyl‐CoA desaturase by dietary linoleic acid

Effects of <b><i>Trans</i></b>-Fatty Acids on Liver Lipid Metabolism in Mice Fed on Diets Showing Different Fatty Acid Composition

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