Comparison of Zinc and Cadmium Coordination Environments in Synthetic Analogues of Carbonic Anhydrase:  Synthesis and Structure of {[PimPri,But]Cd(OH2)(OClO3)}(ClO4)

Kimblin, Clare; Parkin, Gerard

doi:10.1021/ic961007d

Cited by 38 publications

(19 citation statements)

References 25 publications

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“…The same trend is observed for the bonds to nitrogen in 2. The Zn-N(ligand) distance is close to what observed in pyrazolyborate complexes of zinc (2.031 Å ) [27,28].…”

Section: Crystal Studysupporting

confidence: 76%

Synthesis, crystal structures and properties of five-coordinate Schiff-base Zn(II) complexes

Zhu

et al. 2006

Journal of Coordination Chemistry

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Five-coordinate Schiff-base Zn complexes (1,2-cyclohexanediamino-N,N 0 -bis(salicylidene)) zinc-pyridine 1 and (1,2-cyclohexanediamino-N,N 0 -bis(3,5-di-tert-butylsalicylidene)) zincpyridine 2 were synthesized and the structures of 1 and 2 have been determined by single-crystal X-ray analysis. All Zn atoms are five-coordinate in both structures. Both complexes exhibit interesting structures based on intermolecular -stacking and hydrogen bond interactions. Complex 1 has a one-dimensional molecular chain structure via -stacking interaction, while complex 2 has an interesting lattice structure (with cavities with dimensions 10.9 Â 6.9 Å ) formed through intermolecular -stacking and hydrogen bond interactions. 1 and 2 are compared and characterized by MS, elemental analysis, IR, UV-Vis and Photoluminescence (PL). Fluorescence spectra show that the maximal emission wavelength of 1 and 2 are 454 nm, and 480 nm, respectively, upon radiation by UV light. Cyclic voltammetry performed on 1 and 2 indicate a dependence of the cathodic potentials upon conformational and electronic effects. Electronic spectral properties of 1 and 2 were studied by TD-DFT methods. The fluorescent emission of these complexes originates from ligand-centred -* transitions. The Zn (II) centres play a key role in enhancing the fluorescent emission of the ligands.

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“…The same trend is observed for the bonds to nitrogen in 2. The Zn-N(ligand) distance is close to what observed in pyrazolyborate complexes of zinc (2.031 Å ) [27,28].…”

Section: Crystal Studysupporting

confidence: 76%

Synthesis, crystal structures and properties of five-coordinate Schiff-base Zn(II) complexes

Zhu

et al. 2006

Journal of Coordination Chemistry

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“…As already known, the tetrakis Zn 2+ compound of an metalloenzyme temporarily forms a pentahedral resonance structure with the intermediate product, and then the intermediate is released as a product, allowing the Zn 2+ compound to return to a tetrahedral coordination [18]. This process is the key step of the catalytic reaction [19][20][21], and is closely related to the turnover number rather than the Michaelis constant. Based on this reaction mechanism, it is very likely that the tetrahedral Co 2+ coordination might be favored for the conversion of the substrate rather than the hexahedral coordination.…”

Section: Evaluation Of Catalytic Performancementioning

confidence: 99%

Effects of transition metal ions on the catalytic activity of carbonic anhydrase mimics

Keum

Kim

Lee

2015

Journal of Molecular Catalysis A: Chemical

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“…14, possess significantly different structures. 69 Thus, the zinc complex {[Pim Pr i ,Bu t ]ZnOH} + exists as a simple tetrahedral hydroxide derivative, whereas the cadmium counterpart is a five-coordinate aqua complex, {[Pim Pr i ,Bu t ]Cd(OH 2 )-(OClO 3 )} + . In addition to the different structures, the fact that the cadmium center binds a ligand as weakly coordinating as perchlorate is particularly interesting because it indicates that biologically more pertinent anions should also coordinate to a tetrahedral [{N 3 }Cd II (OH 2 )] center and thereby suggests that Cd II -carbonic anhydrase may not be tetrahedral.…”

Section: (A) Influence Of the Metal On Active Site Coordination Geometrymentioning

confidence: 99%

The bioinorganic chemistry of zinc: synthetic analogues of zinc enzymes that feature tripodal ligands

2000

Self Cite

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Zinc, as a constituent of more than 300 enzymes, plays essential roles in biological systems. The active sites of these enzymes feature a zinc center attached to the protein backbone by three or four amino acid residues, the nature of which influences the specific function of the enzyme. In order to understand why different zinc enzymes utilize different amino acid residues at the active site, it is necessary to understand how, and why, the chemistry of zinc is modulated by its coordination environment. Answers to these questions are being provided by a study of synthetic analogues of zinc enzymes, i.e. small molecules that resemble the enzyme active sites. This article provides an account of those studies that have specifically used tripodal ligands to mimic the active site protein residues in an effort to ascertain the bioinorganic chemistry of zinc.

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Comparison of Zinc and Cadmium Coordination Environments in Synthetic Analogues of Carbonic Anhydrase: Synthesis and Structure of {[Pim^Pr^ⁱ^,Bu^{^t}]Cd(OH₂)(OClO₃)}(ClO₄)

Cited by 38 publications

References 25 publications

Synthesis, crystal structures and properties of five-coordinate Schiff-base Zn(II) complexes

Synthesis, crystal structures and properties of five-coordinate Schiff-base Zn(II) complexes

Effects of transition metal ions on the catalytic activity of carbonic anhydrase mimics

The bioinorganic chemistry of zinc: synthetic analogues of zinc enzymes that feature tripodal ligands

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