Abstract:The yeast Saccharomyces cerevisiae and most eukaryotes carry two
5’→3’ exoribonuclease paralogues that are very similar. In yeast, they
are called Xrn1, which shuttles between the nucleus and cytoplasm and
executes major cytoplasmic mRNA decay, and Rat1, which carries a strong
nuclear localization sequence (NLS) and localizes in the nucleus. Xrn1
is 40% homologous to Rat1 but has an extra ~500 amino
acids C-terminal extension. In the cytoplasm, Xrn1 can degrade decapped
mRNAs during the last round of translati… Show more
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