“…Their reliance on intrinsic differences in the number, distribution, and color of intracellular pigment granules as a means to keep track of donor versus host tissues was actually a proxy for a neural crest‐derived lineage (i.e., melanocytes), something which was suggested by Harrison () and others but which remained debatable at the time (Dorris, ; DuShane, ; Harrison, ; Holtfreter, ; Raven, ). Soon thereafter, numerous efforts were underway to determine the extent to which neural crest cells establish inter‐ and intra‐specific pigment patterns and to sort out the effects and/or role of interactions with epidermis (Clark Dalton, ; Harrison, ; Hörstadius, ; Macmillan, ). For example, neural crest transplants among the tiger salamander, spotted salamander, or white and black strains of the Mexican salamander revealed that the “characteristic adult spots of the graft are in most cases distinctly different from those of the host, and are similar to those of donor adults” (DuShane, , p. 25).…”