Comparison of wheat and rye flour solutions for skin prick testing: a multi‐centre study (Stad 1)

Kampen, V. van; Merget, R.; Rabstein, Sylvia; Sander, I.; Bruening, Thomas H.; Broding, Horst Christoph; Keller, C.; Muesken, H; Overlack, A.; Schultze‐Werninghaus, G.; Walusiak, Jolanta; Raulf‐Heimsoth, Monika

doi:10.1111/j.1365-2222.2009.03342.x

Cited by 32 publications

(33 citation statements)

References 24 publications

(20 reference statements)

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“…Tests were performed in duplicate as described recently . A wheal diameter of at least 3 mm in at least one of both tests was defined as positive as it has been shown that small wheal diameters demonstrate the highest test efficiencies (van Kampen et al 2009). …”

Section: Skin Prick Test (Spt)mentioning

confidence: 99%

The German experience 10 years after the latex allergy epidemic: need for further preventive measures in healthcare employees with latex allergy

Merget

Kampen

Sucker

et al. 2010

Int Arch Occup Environ Health

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Section: Skin Prick Test (Spt)mentioning

confidence: 99%

The German experience 10 years after the latex allergy epidemic: need for further preventive measures in healthcare employees with latex allergy

Merget

Kampen

Sucker

et al. 2010

Int Arch Occup Environ Health

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“…The bronchial response to an occupational agent may vary according to its physicochemical characteristics [52][53][54]. Nebulising saline solutions of water-soluble HMW agents has limitations since standardised solutions of occupational agents are lacking (except for latex), and some relevant allergens may not be water soluble [55,56].…”

Section: Methods For Delivering Occupational Agentsmentioning

confidence: 99%

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

Vandenplas

Suojalehto

Aasen

et al. 2014

European Respiratory Journal

177

144

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This consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, a census of active European centres, a Delphi conference and expert consensus. This article details each step of a SIC, including safety requirements, techniques for delivering agents, and methods for assessing and interpreting bronchial responses. The limitations of the procedure are also discussed.Testing should only be carried out in hospitals where physicians and healthcare professionals have appropriate expertise. Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close monitoring of the patient during the challenge and for at least 6 h afterwards. In expert centres, excessive reactions provoked by SIC are rare.A positive response is defined by a fall in forced expiratory volume in 1 s o15% from baseline. Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. The sensitivity and specificity of SIC are high but not easily quantified, as the method is usually used as the reference standard for the diagnosis of occupational asthma. @ERSpublications ERS Task Force: a statement on specific inhalation challenges in the diagnosis of occupational asthma

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“…Nevertheless, it has to be considered that all these evaluations are in fl uenced by the selected 'gold standard' which is in our case the self-reported asthmatic symptoms. Whereas predictive values depend largely on the prevalence rates of cases under study, sensitivity and speci fi city are presumably inherent characteristics of the test (Feinstein 1975 ;van Kampen et al 2009 ) . Thus, we used the Youden Index, considering sensitivity and speci fi city equally to de fi ne the optimal positivity criterion (cut-off level) for each parameter, because this index should be independent of selection bias.…”

Section: Discussionmentioning

confidence: 99%

“…To estimate speci fi c parameters in EBC and IS as suitable diagnostic parameter for the detection of asthmatic symptoms (AS), the self-reported current asthmatic symptoms were taken as the gold standard to calculate sensitivities, speci fi cities, positive predictive values (PPV), negative predictive values (NPV), and test ef fi ciencies. For the evaluation of a parameter, the mediator or cell concentration leading to the maximum Youden Index (sensitivity + speci fi city − 1) was chosen as the optimal cut-off level (as described by van Kampen et al 2009 ) . The data were analyzed by using GraphPad Prism version 5.01 for Windows (GraphPad Software, San Diego, CA).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Different Non-invasive Methods for Detection of Allergic Asthma

Raulf‐Heimsoth

Kampen

Heinze

et al. 2012

Advances in Experimental Medicine and Biology

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Non-invasive methods to assess inflammation of lower airways are induced sputum (IS), exhaled nitric oxide (eNO), and exhaled breath condensate (EBC). Here we focused on the assessment of airway inflammation with a panel of non-invasive methods in health care workers (HCWs) with suspected latex allergy with and without current allergic respiratory symptoms about 10 years after the latex ban in German health care facilities. Seventy-seven non-smoking subjects were examined by skin prick test and specific IgE measurements, eNO, IS, and EBC. Sensitivity, specificity, and positive and negative predicted values for relevant biomarkers were calculated using current asthma symptoms as the gold standard. Twenty-nine subjects (38%) reported ongoing asthmatic symptoms (AS). In these subjects the EBC concentrations of nitrogen oxides (NO(x); p=0.027) and leukotriene B(4) (p=0.025) were significantly higher than in subjects without AS. In addition, in the subjects with AS the numbers of eosinophils (p=0.015) and the concentrations of IL-5 (p= 0.021) in IS samples were significantly higher than in the subjects without AS. A good correlation between several inflammatory markers in IS was detected. The maximum Youden Index was reached for IS total eosinophils ≥3.5·10(4) with a test efficiency of 0.72. In conclusion, non-invasive inflammatory monitoring with EBC and IS may assist the diagnosis of allergic asthma. Self-reported current asthmatic symptoms were reflected by eosinophilic inflammation and the best parameter to support the asthma diagnosis is a total number of eosinophils ≥3.5·10(4) in IS.

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Comparison of wheat and rye flour solutions for skin prick testing: a multi‐centre study (Stad 1)

Cited by 32 publications

References 24 publications

The German experience 10 years after the latex allergy epidemic: need for further preventive measures in healthcare employees with latex allergy

The German experience 10 years after the latex allergy epidemic: need for further preventive measures in healthcare employees with latex allergy

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

Comparison of Different Non-invasive Methods for Detection of Allergic Asthma

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