Comparison of wet combing with malathion for treatment of head lice in the UK: a pragmatic randomised controlled trial

Roberts, Richard J.; Casey, Denise; Morgan, D. A.; Petrovič, Maja

doi:10.1016/s0140-6736(00)02578-2

Cited by 132 publications

(79 citation statements)

References 11 publications

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“…Current study revealed that medication was most widely cure method for treating head louse (72.3%), as compare to combing (15.8%), and procedures (11.9%). Similar results were found by Roberts et al [14]. Rate of head louse was high among students whose parents are illiterate (39.6%).…”

Section: Discussionsupporting

confidence: 89%

Prevalence of Pediculosis among Students in Pakistan

Tufail¹,

Khan²,

Hassan³

2017

Arch Med

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Section: Discussionsupporting

confidence: 89%

Prevalence of Pediculosis among Students in Pakistan

Tufail¹,

Khan²,

Hassan³

2017

Arch Med

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“…The successful off-label use of ivermectin in the United States and worldwide for ectoparasites suggests that this be clinically evaluated for head lice. 2,17,25 And in the United Kingdom, Roberts et al 22 found that a malathion lotion similar to that tested here was about 3 times more effective than extensive wet combing or "bug busting" even in a malathion-resistant population.…”

Section: Commentmentioning

confidence: 62%

“…3,20 The FDA approval confirms that Ovide lotion is the only product we tested with the toxicity profile and data to support an 8-to 12-hour application, even though our in vitro results show that a much shorter exposure time is highly effective. Resistance to malathion has developed in France and the United Kingdom 2,16,22 ; however, the 0.5 % malathion products available in these countries are not the same as Ovide lotion. The Ovide vehicle contains components such as dipentene, terpineol, and 78% isopropanol, which increase the pediculicidal and ovicidal activity of the malathion.…”

Section: Commentmentioning

confidence: 99%

Comparative In Vitro Pediculicidal Efficacy of Treatments in a Resistant Head Lice Population in the United States

Meinking¹,

Serrano²,

Hard³

et al. 2002

Arch Dermatol

122

114

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“…23 A prior study of the nonneurotoxic "Bug Busting" treatment concluded that its 38% cure rate made it inappropriate as a first-line treatment for head lice. 24 The design of this preliminary study was limited by its lack of blinding, randomization, and inclusion of a control or therapeutic comparative group. However, the results of these open clinical trials should still be of great interest to clinicians treating head lice.…”

Section: Discussionmentioning

confidence: 99%

A Simple Treatment for Head Lice: Dry-On, Suffocation-Based Pediculicide

Pearlman¹

2004

Pediatrics

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ABSTRACT. Objectives. The emergence of drug-resistant lice has created the need for new therapies. This study assesses a new method without neurotoxins, extensive household cleaning, or nit removal.Methods. One hundred thirty-three subjects participated in 2 open clinical trials. In the first trial, 93 subjects completed treatment using a nontoxic, dry-on, suffocation-based, pediculicide lotion, minimal household cleaning measures, and physical removal of the nits. In the second trial, 40 subjects completed treatment using an identical protocol except that the nits were not removed. Head lice infestation was defined as a wet combing test showing lice. Cure was defined as a wet combing test showing no lice, with an absence of symptoms. Subjects were contacted 6 months later, for assessment of their disease status.Results. Cure was achieved for 97% of the patients in the first trial and 95% in the second trial. Remission at the follow-up assessment was reported for 77 of 82 subjects (94%) in the first trial and 36 of 38 subjects (95%) in the second trial. There was no statistical difference in cure rates or remission rates between the protocols with and without nit removal. The overall cure rate was 96%, with a remission rate of 94%. There were no adverse effects.Conclusions. Dry-on, suffocation-based, pediculicide lotion effectively treats head lice without neurotoxins, nit removal, or extensive house cleaning. These results are comparable or superior to the results previously reported for treatments with permethrin, pyrethrin, and malathion. Pediatrics 2004;114:e275-e279. URL: http: //www.pediatrics.org/cgi/content/full/114/3/e275; lice, Pediculus humanus var capitis, resistance, permethrin, pyrethrin, malathion.ABBREVIATION. DSP, dry-on, suffocation-based pediculicide.

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Comparison of wet combing with malathion for treatment of head lice in the UK: a pragmatic randomised controlled trial

Cited by 132 publications

References 11 publications

Prevalence of Pediculosis among Students in Pakistan

Prevalence of Pediculosis among Students in Pakistan

Comparative In Vitro Pediculicidal Efficacy of Treatments in a Resistant Head Lice Population in the United States

A Simple Treatment for Head Lice: Dry-On, Suffocation-Based Pediculicide

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