Comparison of Warm Fluid and Cold Fluid Resuscitations During Uncontrolled Hemorrhagic Shock Model in Rats

Dilmen, Serkan; Eryılmaz, Mehmet; Balkan, Salih Müjdat; Serdar, Muhittin; Durusu, Murat; Yıldırım, Ali; Dilmen, Sanem Aslıhan

doi:10.5505/tjtes.2016.50487

Cited by 1 publication

(1 citation statement)

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“…Although several therapies have been developed to treat HH 4 , 5 , the administration of hypertonic saline solution (HSS) has attracted more interest because it produces cardiovascular recovery in smaller volumes 6 . Previous evidence suggests that the hemodynamic effects of HSS are not solely attributed to the plasma volume expansion 7 .…”

Section: Introductionmentioning

confidence: 99%

Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats

Naves

Marques

Mourão

et al. 2018

Sci Rep

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The infusion of hypertonic saline solution (HSS) is known to be beneficial to the treatment of hypovolemic hemorrhage (HH). The central mechanism of HSS-induced cardiovascular and autonomic recovery of animals subjected to HH remains unclear. Hence, the present study evaluated the involvement of median preoptic nucleus (MnPO) and medullary noradrenergic neurons (A1 and A2) in HSS-induced cardiovascular and sympathetic responses in hemorrhagic rats. The wistar rats were subjected to specific lesion of noradrenergic neurons through the nanoinjections of anti-DβH-saporin into caudal ventrolateral medulla (A1 neurons) and nucleus of the solitary tract (A2 neurons). After recovery, mean arterial pressure (MAP) and renal sympathetic nervous activity were recorded. The HH was performed through blood withdrawal until a MAP of 60 mmHg was attained. In sham rats, HSS infusion (3M NaCl) reestablished MAP without change in HH-induced sympathoinhibition. The muscimol (agonist of GABAA receptor) was nanoinjected in MnPO during HH and MnPO inhibition abolished the recovery of MAP and HSS-induced sympathoinhibition. Simultaneous lesions of A1 and A2 abolished MAP restoration and sympathoinhibition after HSS infusion. These results suggest that the recovery of MAP and HSS-induced sympathoinhibition in hemorrhaged rats depend on intact neural projections from A1 and A2 to MnPO.

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Section: Introductionmentioning

confidence: 99%