Comparison of Vonoprazan and Esomeprazole for Eradication of &lt;i&gt;H. pylori&lt;/i&gt; Infection

Matoba, Hideaki; Yoshida, Hiroshi; Suzuki, Tsuyoshi; Seta, Shinsuke; Takata, Hideyuki; Ueda, Jyunji; Maruyama, Hiroshi; Yokoyama, Tadashi; Makino, Hiroshi; Uchida, Eiji

doi:10.1272/manms.13.38

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“…In Phase III clinical trials on eradication therapy using VPZ, the success rate of primary eradication was 92.6% and the success rate of secondary eradication was 98%, showing high eradication rates . A previous study on primary eradication therapy using VPZ showed a higher eradication rate than esomeprazole (EPZ) in clinical practice . Another study reported that the disinfection rate of VPZ is significantly higher in chronic gastritis associated with H. pylori than that of LPZ, rabeprazole or EPZ .…”

Section: Discussionmentioning

confidence: 99%

Cost‐effectiveness analysis and effectiveness of pharmacist‐managed outpatient clinics in Helicobacter pylori eradication therapy

Seko

Tachi

Hatakeyama³

et al. 2019

Int J Clin Pract

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Background Helicobacter pylori is involved in many upper gastrointestinal diseases such as peptic ulcers and gastric cancers. In this study, we compared the cost‐effectiveness of lansoprazole and vonoprazan in H. pylori eradication therapy and examined the effectiveness of pharmacist‐managed outpatient clinics. Methods We investigated the efficacy and cost‐effectiveness of pharmacist‐managed outpatient clinics in H. pylori eradication therapy at our hospital from January 2015 to December 2017. The subjects were classified into three groups: lansoprazole group; vonoprazan group; and the medication instruction group, which received instructions at the pharmacist‐managed outpatient clinics (intervention group). We examined the eradication rate and cost‐effectiveness ratio of each group. Results The eradication rate of primary eradication therapy was 75.2% in the lansoprazole group, 87.8% in the vonoprazan group and 91.4% in the intervention group. When mental component summary was used as quality of life score, cost‐effectiveness ratio was 224.7 yen in lansoprazole group, 223.9 yen in vonoprazan group and 222.2 yen in intervention group. Setting up pharmacist‐managed outpatient clinics increases the pharmacist labour cost necessary for eradication therapy. However, if the medication instructions provided by the pharmacist can lead to improved disinfection efficiency, improvement in cost efficiency can be expected. Conclusion Although medication instructions provided at the pharmacist‐managed outpatient clinics incur additional labour costs, they improve patient quality of life as well as disinfection rate in H. pylori eradication therapy. Therefore, pharmacist‐managed outpatient clinics are useful from the viewpoint of pharmacoeconomics.

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Section: Discussionmentioning

confidence: 99%