Abstract:Objectives: Rheumatoid arthritis (RA) and ulcerative colitis (UC) are two autoimmune diseases where patients report high levels of fatigue, pain, and depression. The effect of systemic inflammation from these diseases is likely affecting the brain, however, it is unknown whether there are measurable neuroanatomical changes and whether these are a contributing factor to these central symptoms. Methods: We included 258 RA patients with 774 age and sex matched controls and 249 UC patients with 747 age and sex mat… Show more
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