Comparison of Vitros Dry Slide Technology for Determination of Lithium Ions with Other Methods

Serdarevic, Nafija; Malešič, Ivan; Kozjek, F.

doi:10.17305/bjbms.2006.3191

Cited by 5 publications

(5 citation statements)

References 3 publications

(3 reference statements)

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“…They can detect Li + concentration as low as 10 μM, which is substantially lower than the concentration of Li + in non-invasively retrievable biofluids (e.g., saliva: 0.5-3 mM; ∼ double the corresponding serum concentrations). [23,24] Furthermore, Figure S2C (Supporting Information) shows that the sensor's response to the variations of interfering ions was minimal as compared to that of Li + , demonstrating good selectivity in the envisioned clinical application.…”

Section: Resultsmentioning

confidence: 99%

Non‐Invasive Touch‐Based Lithium Monitoring Using an Organohydrogel‐Based Sensing Interface

Lin

Zhu

Yeung

et al. 2023

Adv Materials Technologies

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Lithium is a drug widely employed for the treatment of bipolar disorder owing to its high efficacy in mood management and suicide prevention. However, this efficacy is often undermined by misdosing and nonadherence, and diligent drug monitoring is required during treatment. Standard lithium monitoring involves invasive blood collections and laboratory analysis with low time granularity. Recent advances in sensor technology have enabled the development of personalized drug-monitoring devices that analyze biomarker information noninvasively. Herein, based on the fact that the analyte partition onto the fingertip with a high flux, a touch-based noninvasive monitoring modality for managing lithium pharmacotherapy is devised. The system is built based on a thin organohydrogel-mounted lithium ion-selective electrode (TOH-ISE). The TOH coating provides a stable environment for sensing. Through the utilization of a water/glycerol bi-solvent matrix, the gel exhibits dehydration-resist properties, rendering a controlled micro-environment for ISE conditioning, and subsequently minimizing signal drift. To illustrate the clinical application of the solution, the system is tested on a subject prescribed lithium. The system successfully detected the increase in circulating drug levels following medication intake. Collectively, the results indicate the devised solution is capable to facilitate lithium adherence monitoring and has broader potential for optimizing lithium pharmacotherapy.

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Section: Resultsmentioning

confidence: 99%

Non‐Invasive Touch‐Based Lithium Monitoring Using an Organohydrogel‐Based Sensing Interface

Lin

Zhu

Yeung

et al. 2023

Adv Materials Technologies

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“…From the literature, Serdarević N et al have compare the lithium values obtained from the ISE method with Vitros dry chemistry method and atomic spectrophotometry method, where they have mentioned that there was a positive interference in the ISE method. The Vitros dry slide technology method provides reliable lithium concentration results and is a valid alternative to Atomic Absorption Spectrometry method [14].…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Sahu¹,

Sahoo²,

Chatterjee³

et al. 2023

Preprint

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Background: The collection of blood samples in different vacutainers can affect the result of serum lithium estimation due to the presence of distinct additives added in the blood collection vacutainer for enhancing the clot formation process. The presence of these additives has proven to interfere with laboratory results of biochemical analytes. In this case, both the pre-analytical and the analytical phases have a significant impact on the accuracy and precision of the test result. Thus, it has become a challenge for the lab physician to estimate lithium in any clinical laboratory setup. Materials and Methods: In total, 100 patient samples were collected and paired into clot activator vacutainers and plain glass vials. Both the paired collecting tubes after centrifugation were processed immediately via Vitros 4600 analyzer working on the principle of reflectance photometry. Both the paired tubes were stored at 2-8 degrees centigrade and were further analyzed, at 24 and 48 hours respectively, from the time of their collection. The statistical analysis was done in IBM SPSS software version 23. Results: There was a significant difference in the lithium values obtained from clot activator vacutainers in comparison to glass vial. The difference between the measurements of the lithium levels was statistically tested by t test where it was observed that the lithium measurements by the two different collecting tubes differed significantly with a Confidence Interval of 0.03 to 0.06 implying the level of agreement of both the methods are not similar. But there was no statistical difference in the lithium values estimated at 24 hours and 48 hours of collection. Conclusion: In this study, lithium levels measured by clot-activated vacutainers are found to be low as compared to lithium levels measured through glass vials. There is no apparent change in lithium values obtained at 1hr, 24hrs and 48hrs from their collection, when measured from the glass vials and the clot-activated vacutainers respectively, by the Vitros 4600 dry chemistry analyzer.

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“…The VITROS dry slide technology method provides reliable Li concentration results and is a valid alternative to atomic absorption spectrometry method. 15 ►Table 2 explains the decreased value of Li in the clot activator vacutainers that may be due to the presence of silica additives in the silicone-coated vacutainers that on exposure of the Li by dry chemistry analyzer results in decreased Li values. Crown ethers are well known for binding metal cations due to their cyclic cavities and electron donor features.…”

Section: Discussionmentioning

confidence: 99%

“…The VITROS dry slide technology method provides reliable Li concentration results and is a valid alternative to atomic absorption spectrometry method. 15 …”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Serum Lithium Estimation Using Plain Glass Vial and Serum Clot Activator Vacutainer by Reflectance Photometry

et al. 2023

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Background The collection of blood samples in different vacutainers can affect the result of serum lithium estimation due to the presence of distinct additives in the blood collection vacutainer for enhancing the clot formation process. Due to the low therapeutic index and threat of toxicity of lithium, it is imperative to correctly report the test result. Thus, it has become a challenge for the laboratory physician to estimate lithium in any clinical laboratory setup. Materials and Methods Sample of 100 patients were collected and paired into clot activator vacutainers and plain glass vials. After centrifugation, samples from the paired collection tubes were processed immediately for serum lithium estimation by VITROS 4600 analyzer working on the principle of reflectance photometry. Both the paired tubes were stored at 2 to 8°C and were further analyzed, at 24 and 48 hours, respectively, from the time of their collection. The statistical analysis was done in IBM SPSS software version 23. Results There was a statistically significant differences between the mean of lithium values when processed within 1st hour of collection, obtained from clot activator vacutainers in comparison to glass vials. However, within tube comparison, there was no statistical difference in the lithium values estimated at 1st hour, 24 hours, and 48 hours of collection. Conclusion In this study, lithium values measured by clot-activated vacutainers are found to be lower as compared with values measured through glass vials.

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Comparison of Vitros Dry Slide Technology for Determination of Lithium Ions with Other Methods

Cited by 5 publications

References 3 publications

Non‐Invasive Touch‐Based Lithium Monitoring Using an Organohydrogel‐Based Sensing Interface

Non‐Invasive Touch‐Based Lithium Monitoring Using an Organohydrogel‐Based Sensing Interface

Comparative evaluation of serum lithium estimation in serum samples using plain glass vial and serum clot activator vacutainer by reflectance photometry principle

Comparative Evaluation of Serum Lithium Estimation Using Plain Glass Vial and Serum Clot Activator Vacutainer by Reflectance Photometry

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